JER [Journal of Exercise Rehabilitation]

간행물 정보
  • 자료유형
  • 발행기관
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • ISSN
  • 간기
  • 수록기간
  • 등재여부
  • 주제분류
    의약학 > 재활의학
  • 십진분류
    KDC 514.03 DDC 617.03
Vol.10 No.1 (8건)




Khae-Hawn Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 p.1

※ 원문제공기관과의 협약에 따라 개인회원에게 무료로 제공됩니다.

Although the ageing process is poorly understood, scientists do know that it is caused by many factors. There is some evidence that telomere erosion contributes to age-associated human pathology. However, it is definitely not the only, or even dominant cause, although it has been proven that ageing was accelerated in mice engineered to lack in telomerase. Other factors such as highly reactive particles called free radicals which are made naturally in the body cause damage to cells, as well as smoking, ultraviolet light, and other environmental factors. Another concern of telomerase reactivation is that it is a hallmark of most human cancers. Despite such revolutional discoveries, the obstacles we must overcome in order to find the key to rejuvenation are almost overwhelming, but through our effort, they may be surmountable.

Original Article


Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats

Bo-Kyun Kim, Mal-Soon Shin, Chang-Ju Kim, Sang-Bin Baek, Yeong-Chan Ko, Young-Pyo Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.2-8

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Alzheimer’s disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impair-ment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer’s disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise on short-term memory in relation with neurogenesis in the rats with amyloid β25-35 (Aβ25-35)-induced Alzheimer’s disease. The rat model of Alzheimer’s dis-ease was induced by the intracerebroventricular (ICV) injection of Aβ25-35, using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 4 consecutive weeks, starting 2 days after Aβ25-35 injection. Presently, short-term memory was deteriorated and apical dendritic length in the hippocampus was short-ened in the hippocampus by Aβ25-35 injection. In contrast, treadmill exer-cise alleviated memory impairment and increased apical dendritic length in the Aβ25-35-injected rats. Neurogenesis and brain-derived neurotor-phic factor (BDNF) and tyrosine kinase B (trkB) in the hippocampal den-tate gyrus were decreased by Aβ25-35 injection. Treadmill exercise in-creased neurogenesis and expressions of BDNF and trkB expressions. The present study shows that treadmill exercise may provide therapeu-tic value for the alleviating symptoms of Alzheimer’s disease.



Effects of endurance exercise on expressions of glial fibrillary acidic protein and myelin basic protein in developing rats with maternal infection-induced cerebral palsy

Kijeong Kim, Mal-Soon Shin, Han-Sam Cho, Young-Pyo Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.9-14

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Periventricular leukomalacia (PVL) is a common white matter lesion af-fecting the neonatal brain. PVL is closely associated with cerebral palsy (CP) and characterized by increase in the number of astrocytes, which can be detected by positivity for glial fibrillary acidic protein (GFAP). Change in myelin basic protein (MBP) is an early sign of white matter abnormality. Maternal or placental infection can damage the neonatal brain. In the present study, we investigated the effects of treadmill walk-ing exercise on GFAP and MBP expressions in rats with maternal lipo-polysaccharide (LPS)-induced PVL. Immunohistochemistry was per-formed for the detection of GFAP and MBP. The present results showed that intracervical maternal LPS injection during pregnancy increased GFAP expression in the striatum and decreased MBP expression in the corpus callosum of rats. The results also showed that treadmill walking exercise suppressed GFAP expression and enhanced MBP expression in the brains of rats with maternal LPS-induced PVL. The present study revealed that treadmill walking exercise is effective for the suppressing astrogliosis and hypomyelination associated with PVL. Here in this study, we showed that treadmill walking exercise may be effective therapeu-tic strategy for alleviating the detrimental effects of CP.



Treadmill exercise enhances NMDA receptor expression in schizophrenia mice

Joon-Ki Park, Sam-Jun Lee, Tae-Won Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.15-21

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Schizophrenia is a serious psychiatric disorder with several symptoms including cognitive dysfunction. Although the causes of schizophrenia are still unclear, there is a strong suspicion that the abnormality in N- methyl-D-aspartate (NMDA) receptor may contribute to schizophrenia symptoms. In the present study, the effect of treadmill exercise on the NMDA receptor expression was evaluated using MK-801-induced schizophrenia mice. Immunohistochemistry for expressions of NMDA receptor tyrosine hydroxylase (TH) was conducted. Western blot for brain-derived neurotrophic factor (BDNF) was also performed. In the present results, the mice in the MK-801-treated group displayed re-duced NMDA receptor expression. Enhanced TH expression and sup-pressed BDNF expression were also observed in the MK-801-treated mice. Treadmill exercise improved NMDA receptor expression in the MK-801-induced schizophrenia mice. Treadmill exercise also suppressed TH expression and enhanced BDNF expression in the MK-801-in-duced schizophrenia mice. The present study showed that down-regu-lation of NMDA receptor demonstrated schizophrenia-like parameters, meanwhile treadmill running improved schizophrenia-related parame-ters through enhancing NMDA receptor expression.



Treadmill exercise ameliorates symptoms of attention deficit/hyperactivity disorder through reducing Purkinje cell loss and astrocytic reaction in spontaneous hypertensive rats

Hyo-Soon Yun, Mi-Sook Park, Eun-Sang Ji, Tae-Woon Kim, Il-Gyu Ko, Hyun-Bae Kim, Hong Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.22-30

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Attention deficit/hyperactivity disorder (ADHD) is a neurobehavioral disorder of cognition. We investigated the effects of treadmill exercise on Purkinje cell and astrocytic reaction in the cerebellum of the ADHD rat. Adult male spontaneously hypertensive rats (SHR) and Wistar-Kyo-to rats (WKYR) weighing 210±10 g were used. The animals were ran-domly divided into four groups (n=15): control group, ADHD group, ADHD and methylphenidate (MPH)-treated group, ADHD and treadmill exercise group. The rats in the MPH-treated group as a positive control received 1 mg/kg MPH orally once a day for 28 consecutive days. The rats in the treadmill exercise group were made to run on a treadmill for 30 min once a day for 28 days. Motor coordination and balance were determined by vertical pole test. Immunohistochemistry for the expres-sion of calbindinD-28 and glial fibrillary acidic protein (GFAP) in the cer-ebellar vermis and Western blot for GFAP, Bax, and Bcl-2 were con-ducted. In the present results, ADHD significantly decreased balance and the number of calbindin-positive cells, while GFAP expression and Bax/Bcl-2 ratio in the cerebellum were significantly increased in the ADHD group compared to the control group (P<0.05, respectively). In contrast, treadmill exercise and MPH alleviated the ADHD-induced the decrease of balance and the number of calbindine-positive cells, and the increase of GFAP expression and Bax/Bcl-2 ratio in the cerebellum (P<0.05, respectively). Therefore, the present results suggested that treadmill exercise might exert ameliorating effect on ADHD through re-duction of Purkinje cell loss and astrocytic reaction in the cerebellum.



Effects of rehabilitative horse riding on the Sit-to-Stand action of the adolescent with brain lesions

Jang Won Lee, A-reum Han, Kihong Kim

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.31-34

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The purpose of this study was to investigate the balance abilities of the adolescent girl with brain lesions by Sit-to-Stand (STS) action analysis before and after the rehabilitative horse riding of 16 week program. The subject aged 16 yr old who had the disabilities of spasticity and hemi-plegia was recruited with the consent approval. The equilibrium abilities of the subject were tested by Sit-to-Stand examination with Weight Transfer Time (WTT), Mean Rising Index (MRI), Mean Weight Asymme-try (MWA), Max Trunk Flexion Velocity (MTFV), and Max Trunk Exten-sion Velocity (MTEV). Research was designed by AB single subject study with baseline of 3 times of measurement and rehabilitative horse riding treatments. In the results, the enhancement of the subject’s equi-librium ability was shown from the comparisons between baseline and treatment by the STS test that WTT was 2.37 sec faster, MRI was 6.64 N/kg higher, and MWA was 8.12% lower, and MTFV was 0.57°/sec larg-er than all those means of baseline. It suggested that the subject showed her enhanced balance ability while in sitting and standing after the re-habilitative horse riding treatments.



A 12-week rehabilitation program improves body composition, pain sensation, and internal/external torques of baseball pitchers with shoulder impingement symptom

Jun-Youl Cha, Jae-Hak Kim, Ju Hong, Young-Tae Choi, Min-Ho Kim, Ji-Hyun Cho, Il-Gyu Ko, Yong-Seok Jee

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.35-44

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The aim of this study was to investigate the effects of a 12-week reha-bilitation program on body composition, shoulder pain, and isokinetic internal/external torques of pitchers with impingement syndrome. A to-tal of 30 pitchers were divided into 2 groups: experimental group (EG, n =16) and control group (CG, n=14). The rehabilitation program consist-ed of physical therapy, warm-up, work-out, and cool-down. As results, body weight and fat mass of EG were decreased whereas muscle mass of EG was significantly increased after the experiment. The pain de-grees in resting, normal daily activity, and strenuous activity on the nu-meric pain rating scale were significantly decreased in the EG. The in-ternal and external peak torques (PTs) of uninvolved and involved sides of EG were increased in EG after 12 weeks. Such results provide a defi-cit ratio of both sides in EG close to normal values. The ratios of internal/ external PTs in EG were also close to the reference values. The internal and external total works of both sides in EG were similar to the values of PT. The fatigue indices of internal and external rotators of both sides in EG were decreased. As a conclusion, a 12-week rehabilitation pro-gram reduced the shoulder pain, improved the body composition and enhanced the isokinetic shoulder internal/external rotators in EG with impingement symptoms. Also the study suggested that the rehabilita-tion program evened out the ratio between internal and external rota-tors and lowered the fatigue level after the experiment.



Factors influencing physical activity in older adults

Chae-Hee Park, Steriani Elavsky, Kyo-Man Koo

한국운동재활학회 JER Vol.10 No.1 2014.02 pp.45-52

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The purpose of this study was to investigate the extent to which Korean seniors report employing different motivational and social cognitive strategies related to physical activity, and to evaluate which motivation-al and social cognitive strategies were related to physical activity, and which motivational and social cognitive strategies differentiate between high active and low-active Korean seniors. Community-dwelling older adults (N=187) participated in the study and completed questionnaires assessing self-reported physical activity and a range of motivational and social cognitive variables. The results showed that physical activity was predicted by quality goal-setting practices, self-efficacy, social support from family and physical activity self-regulation subscales of social support and exercise planning and scheduling. Between the groups of highly physically active and low-active participants, we ob-served differences in satisfaction with life, self-efficacy, quality goal- setting practices, and self-regulatory strategies related to self-monitor-ing, goal-setting, social support and time management. In conclusion, these findings indicate that physical activity promotion efforts among Korean older adults should focus on enhancing self-efficacy, social support, and self-regulation skills.


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