Earticle

초록

영어

Schizophrenia is a serious psychiatric disorder with several symptoms including cognitive dysfunction. Although the causes of schizophrenia are still unclear, there is a strong suspicion that the abnormality in N- methyl-D-aspartate (NMDA) receptor may contribute to schizophrenia symptoms. In the present study, the effect of treadmill exercise on the NMDA receptor expression was evaluated using MK-801-induced schizophrenia mice. Immunohistochemistry for expressions of NMDA receptor tyrosine hydroxylase (TH) was conducted. Western blot for brain-derived neurotrophic factor (BDNF) was also performed. In the present results, the mice in the MK-801-treated group displayed re-duced NMDA receptor expression. Enhanced TH expression and sup-pressed BDNF expression were also observed in the MK-801-treated mice. Treadmill exercise improved NMDA receptor expression in the MK-801-induced schizophrenia mice. Treadmill exercise also suppressed TH expression and enhanced BDNF expression in the MK-801-in-duced schizophrenia mice. The present study showed that down-regu-lation of NMDA receptor demonstrated schizophrenia-like parameters, meanwhile treadmill running improved schizophrenia-related parame-ters through enhancing NMDA receptor expression.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Materialsimmunohistochemistrydescribed
  Experimental animals and design
  Exercise protocol
  Tissue preparation
  NMDA receptors immunohistochemistry
  Tyrosine hydroxylase immunohistochemistry
  Western blot for BDNF expression
 RESULTS
  Effect of treadmill exercise on the number of NMDA receptor-positive cells in the dentate gyrus.
  Effect of treadmill exercise on the number of NMDA receptor-positive cells in the prefrontal cortex
  Effect of treadmill exercise on the TH expression in the striatum
  Effects of treadmill exercise on the BDNF expression in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Joon-Ki Park [ Division of Exercise and Health Science, College of Arts and Physical Education, Incheon National University, Incheon, Korea ]
• Sam-Jun Lee [ Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea ]
• Tae-Won Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613