Earticle

초록

영어

Periventricular leukomalacia (PVL) is a common white matter lesion af-fecting the neonatal brain. PVL is closely associated with cerebral palsy (CP) and characterized by increase in the number of astrocytes, which can be detected by positivity for glial fibrillary acidic protein (GFAP). Change in myelin basic protein (MBP) is an early sign of white matter abnormality. Maternal or placental infection can damage the neonatal brain. In the present study, we investigated the effects of treadmill walk-ing exercise on GFAP and MBP expressions in rats with maternal lipo-polysaccharide (LPS)-induced PVL. Immunohistochemistry was per-formed for the detection of GFAP and MBP. The present results showed that intracervical maternal LPS injection during pregnancy increased GFAP expression in the striatum and decreased MBP expression in the corpus callosum of rats. The results also showed that treadmill walking exercise suppressed GFAP expression and enhanced MBP expression in the brains of rats with maternal LPS-induced PVL. The present study revealed that treadmill walking exercise is effective for the suppressing astrogliosis and hypomyelination associated with PVL. Here in this study, we showed that treadmill walking exercise may be effective therapeu-tic strategy for alleviating the detrimental effects of CP.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Exercise protocol
  Tissue preparation
  GFAP and MBP immunohistochemistry
  Data analysis
 RESULTS
  Effects of treadmill walking exercise on body weight in rats with maternal endotoxin-induced PVL
  Effect of treadmill walking exercise on GFAP expression in the striatum of rats with maternal endotoxin-induced PVL
  Effect of treadmill walking exercise on MBP expression in the corpus callosum of rats with maternal endotoxin-induced PVL
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Kijeong Kim [ School of Exercise and Sport Science, University of Ulsan, Ulsan, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Han-Sam Cho [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Young-Pyo Kim [ Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613