Earticle

초록

영어

Alzheimer’s disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impair-ment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer’s disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise on short-term memory in relation with neurogenesis in the rats with amyloid β25-35 (Aβ25-35)-induced Alzheimer’s disease. The rat model of Alzheimer’s dis-ease was induced by the intracerebroventricular (ICV) injection of Aβ25-35, using a stereotaxic instrument. The rats in the exercise group were forced
to run on a treadmill for 30 min once daily for 4 consecutive weeks, starting 2 days after Aβ25-35 injection. Presently, short-term memory was deteriorated and apical dendritic length in the hippocampus was short-ened in the hippocampus by Aβ25-35 injection. In contrast, treadmill exer-cise alleviated memory impairment and increased apical dendritic length in the Aβ25-35-injected rats. Neurogenesis and brain-derived neurotor-phic factor (BDNF) and tyrosine kinase B (trkB) in the hippocampal den-tate gyrus were decreased by Aβ25-35 injection. Treadmill exercise in-creased neurogenesis and expressions of BDNF and trkB expressions. The present study shows that treadmill exercise may provide therapeu-tic value for the alleviating symptoms of Alzheimer’s disease.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals and treatments
  ICV administration of Aβ25-35
  Treadmill exercise protocol
  Step-through avoidance task
  Tissue preparation
  BrdU immunohistochemistr
  DCX immunohistochemistry
  Dendritic morphological analysis
  Western blot analysis for BDNF and TrkB
  Data analysis
 RESULTS
  Effect of treadmill exercise on short-term memory in the step-through avoidance task
  Effect of treadmill exercise on neurogenesis in the hippocampal dentate gyrus
  Effect of treadmill exercise on apical dendritic length in the hippocampal dentate gyrus
  Effect of treadmill exercise on expressions of BDNF and TrkB in the hippocampus
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Bo-Kyun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Bin Baek [ Department of Psychiatry, Gangneung Asan Hospital, Ulsan University, Gangneung, Korea ]
• Yeong-Chan Ko [ Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea ]
• Young-Pyo Kim [ Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613