Earticle

Many abnormal climate events are occurring around the world. The cause of abnormal climate is related to temperature. Factors that affect temperature include excessive emissions of carbon and greenhouse gases from a global perspective, and air circulation from a local perspective. Due to the air circulation, many abnormal climate phenomena such as abnormally high temperature and abnormally low temperature are occurring in certain areas, which can cause very serious human damage. Therefore, the problem of abnormal temperature should not be approached only as a case of climate change, but should be studied as a new category of climate crisis. In this study, we proposed a model for the classification of abnormal temperature using random forests based on various meteorological data such as longitudinal observations, yellow dust, ultraviolet radiation from 2018 to 2022 for each region in Korea. Here, the meteorological data had an imbalance problem, so the imbalance problem was solved by oversampling. As a result, we found that the variables affecting abnormal temperature are different in different regions. In particular, the central and southern regions are influenced by high pressure (Mainland China, Siberian high pressure, and North Pacific high pressure) due to their regional characteristics, so pressure-related variables had a significant impact on the classification of abnormal temperature. This suggests that a regional approach can be taken to predict abnormal temperatures from the surrounding meteorological environment. In addition, in the event of an abnormal temperature, it seems that it is possible to take preventive measures in advance according to regional characteristics.

Female breast cancer is the fifth highest cause of mortality. Breast cancer is the most prevalent type of cancer in women globally, while it can also affect men. STAT5A plays a role in its development and progression. Given that activation of STAT5a is frequently linked to the growth and progression of tumors, STAT5a has been identified as a possible target for the therapy of several cancers. STAT5A, in particular, has proven to be overexpressed in various breast cancer cell lines and tumors, and it has been associated to the promotion of tumour cell proliferation and survival. STAT5A inhibition has been shown in vitro and in vivo to reduce the development of breast cancer cells. As a result, we have screened compounds from the FDA database that might serve as potential inhibitors of STAT5a through virtual screening, docking, DFT and MD simulation approaches. The drug Nilotinib has shown promising results inhibiting STAT5a. Further, in-vitro analysis will be carried forward to understand the anti-cancer activity.

Several anti-inflammatory small molecules have been found in the process of the inflammatory response, and these small molecules have been used to treat some inflammatory and autoimmune diseases. Numerous tools for predicting anti-inflammatory peptides (AIPs) have emerged in recent years. However, conducting experimental validations in the lab is both resource-intensive and time-consuming. Current therapies for inflammatory and autoimmune disorders often involve nonspecific anti-inflammatory drugs and immunosuppressants, often with potential side effects. AIPs have been used in treating inflammatory illnesses like Alzheimer's disease and can limit the expression of inflammatory promoters. Recent advances in adverse incident predictions (AIPs) have been made, but it is crucial to acknowledge limitations and imperfections in existing methodologies.

Calcium ions play an important role in development and intracellular signaling . Dictyostelium discoideum has 14 genes encoding calcium -binding proteins (CBPs), but the function of most CBPs during development has not yet been studied . In this study, we investigated the specific functions of CBP7, one of 14 CBPs, in development using RNA interference cell lines of CBP 7, cell lines overexpressing CBP 7, cell lines with point mutations in the EF-hand domain , and cell lines expressing fragment proteins . was intended to reveal. CBP7 consists of 169 amino acids and contains 4 EF-hand domains. The CBP7-overexpressing cells showed complete loss of developmental process . These cells remained in the single-cell growth stage under development -inducing conditions , while wild-type cells formed aggregations within 6– 8 h of development and eventually formed fruiting bodies . The experiments using point-mutated CBP7 protein showed that all EFhand domains of CBP7 were important for CBP7 to function during developmental process . These results suggest that CBP 7 plays an important role in developmental processes across all EF-hand domains.