Earticle

Neuropeptide Y (NPY), a 36-amino acid polypeptide, is a member of the pancreatic polypeptide family, which consists of NPY, peptide YY (PYY) and pancreatic polypeptide (PP). The neuropeptide Y (NPY) receptors called Y receptors belongs to G-protein coupled that are involved in a variety of physiological functions such as appetite regulation, circadian rhythm and anxiety. Five receptor subtypes have been cloned in mammals (Y1, Y2, Y4, Y5, and Y6) of which four are functional. In this short review, information about the functional NYP receptors was analyzed. Sequence analyses were done between these receptors to identify the relationships between them. Phylogram was generated between these receptors to identify the close homologue between these receptors. Our sequence analyses found that Y1 and Y4 receptors are close than the other receptors. Further structure based analysis could be useful to identify subtype selective antagonists and dual antagonists targeting Y1 and Y4 receptors.

Multidrug resistance is a major obstacle in cancer chemotherapy. Cancer cells efflux chemotherapeutic drug out of cell by means of transporter and reduce the active concentration of it inside cell. Such transporters are member of the ATP binding cassettes (ABC) protein. It includes P-gp, multiple resistant protein (MRP), and breast cancer resistant protein (BCRP). These proteins are widely distributed in the human cells such as kidney, lung, endothelial cells of blood brain barrier etc. However, there are number of drugs developed for it, but most of them are getting transported by it. So, still there is necessity of a good modulator, which could effectively combat the transport of chemotherapeutic agents. Natural products origin modulators were found to be effective against transporter such as flavonoids, which belongs to third generation modulators. They have advantage over synthetic inhibitor in the sense that they have simple structure and abundant in nature. This review focuses on the P-gp structure its architecture, efflux mechanism, herbal inhibitors and their mechanism of action. Key words : Human P-gp, Anticancer,

Trialkyltin n-Bu3SnH, an endocrine disruptor, was slowly converted by the catalytic action of group 4 Cp2MCl2/Red- Al (M = Ti, Zr, Hf) to produce two phases of products: one is an insoluble cross-linked solid, polystannane in 7-23% yield as minor product via redistribution/dehydrocoupling combination process, and the other is an oil, hexabutyldistannane in 69-90% yield as major product via simple dehydrocoupling process. Redistribution/dehydrocoupling process first produced a low-molecular-weight oligostannane possessing partial backbone Sn-H bonds which then underwent an extensive cross-linking reaction of backbone Sn-H bonds, leading to an insoluble polystannane. This is the first exciting example of redistribution/dehydrocoupling of a tertiary hydrostannane catalyzed by early transition metallocenes.

Some recommended procedures for obtaining aldehydes from carboxylic acid itself and its derivatives, which have been developed in relatively recent years, are summarized. Such procedures should provide a new practical methodology to synthesize the desired aldehyde products in high yields.

A newly-devised Meerwein-Ponndorf-Verley (MPV) reagents, such as diisobutylacetoxyalanes and diisobutylmethanesulfonylalanes, achieved a clean conversion of unsymmetrical epoxides to the corresponding less substituted alcohols. This review covers the recent developments for such a regiospecific ring-opening reaction of epoxides.

Herbal medicines have been used since the dawn of civilization to maintain health and to treat diseases. Diabetes mellitus is one of the leading cause of death in many developed countries. The incidence of diabetes is increasing at an alarming rate in India. It was estimated that India which had 19.4 million diabetes in 1995 is expected to register a near threefold increase by. Many plants reported to be useful for the treatment of diabetes mellitus in ayurvedic medicine, are being tested for their hypoglycemic activity in experimental animals Lagerstroemia flos- reginae is one such plant commonly found as shade trees in Kerala. In Ayurveda both root and leaves are used in the treatment of diabetes. The main objective of this study was to assess the antidiabetic effect of the alcohol extracted leaves of Lagerstroemia flos- reginae in alloxan induced diabetic rats in terms of controlling blood glucose level, lipid profile, bilirubin, uric acid in serum and lipid peroxides and glutathione in the liver of the experimental animals. The present study has been undertaken to observe the protective effect of the active constituents of Lagerstroemia flos- reginae leaf extracts against alloxan induced diabetes in experimental animal model. The activity of the active constituents was compared with Daonil –a standard drug.

Polymerization of monomeric amyloid-β peptides (Aβ) into soluble oligomers and insoluble fibrils is one of the major pathways triggering the pathogenesis of Alzheimer’s disease (AD). Using small molecules to prevent the polymerization of Aβ peptides can, therefore, be an effective therapeutic strategy for AD. In this study, we investigated the effects of mono- and bi-flavonoids on Aβ42 toxicity and fibrillogenesis and found that the bi-flavonoid, taiwaniaflavone (TF) effectively and specifically inhibits Aβ toxicity and fibrillogenesis. Compared to TF, the mono-flavonoid apigenin (AP) is less effective and less specific. Our data showed that differential effects of the mono- and bi-flavonoids on Aβ fibrillogenesis correlate with their varying cytoprotective efficacies. We also found that other bi-flavonoids, namely 2’,8”- biapigenin, amentoflavone, and sumaflavone, can also effectively inhibit Aβ toxicity and fibrillogenesis, implying that the participation of two mono-flavonoids in a single bi-flavonoid molecule enhanced their activity. Bi-flavonoids, while strongly inhibited Aβ fibrillogenesis, accumulated nontoxic Aβ oligomeric structures, suggesting that these are offpathway- oligomers. Moreover, TF abrogated the toxicity of preformed Aβ oligomers and fibrils, indicating that TF and other bi-flavonoids may also reduce the toxicity of toxic Aβ species. Altogether, our data clearly show that bi-flavonoids, possibly due to the possession of two Aβ binders separated by an appropriate size linker, are likely to be promising therapeutics to suppress Aβ toxicity.

This paper describes the algorithm that lowers the dimension, maintains the gesture recognition and significantly reduces the eigenspace configuration time by combining the higher correlation feature information and Principle Component Analysis. Since the suggested method doesn't require a lot of computation than the method using existing geometric information or stereo image, the fact that it is very suitable for building the real-time system has been proved through the experiment. In addition, since the existing point to point method which is a simple distance calculation has many errors, in this paper to improve recognition rate the recognition error could be reduced by using several successive input images as a unit of recognition with K-Nearest Neighbor which is the improved Class to Class method.

Polymerization of vinyl monomers is promoted by thianthrene cation radical as a part of our research concerning the reactions of various agents with readily isolable, yet highly reactive species and elucidate the biological activity. Thianthrene cation radical initiated the homopolymerization and copolymerization of styrene and ethyl vinyl ether. The polymerization yields decreased as the concentration of phenylacetylene or diphenylethylene increased. Such polymereization by cationic thianthrene radical could provide some clues for the reaction in living animals. Comments on possible polymerization mechanisms were suggested.

Bae and Kim displayed a sequence of 4th degree self-reciprocal polynomials whose maximal zeros are related in a very nice and far from obvious way. Kim showed that the auxiliary polynomials in their results are related to Chebyshev polynomials. In this paper, we study two sequences of polynomials satisfying the recurrence of the auxiliary polynomials with generalized initial conditions. We obtain same results with the auxiliary polynomials from a sequence, and some interesting conjectural properties about resultants and discriminants from another sequence.

The reduction of efficiency of missing observations on complete diallel cross designs are examined. we studies robustness of optimal block designs for estimating general combining ability against loss of missing observations in diallel cross. A-efficiencies suggest that these designs are fairly robust. Simple g-inverses may be found for the information matrices of the line effects which allow evaluation of expressions for the variances of the differences between the pairs of line effects with missing observations. we numerically calculate the reduction of efficiency for estimating general combining ability against loss of missing observations in diallel cross.