Earticle

Single-crystalline silicon nanowire arrays (SiNWAs) using electroless metal-assisted etchings of p-type silicon were successfully fabricated. Ag nanoparticle deposition on silicon wafers in HF solution acted as a localized microelectrochemical redox reaction process in which both anodic and cathodic process took place simultaneously at the silicon surface to give SiNWAs. The growth effect of SiNWs was investigated by changing of etching times. The morphologies of SiNWAs were obtained by SEM observation. Well-aligned nanowire arrays perpendicular to the surface of the silicon substrate were produced. Optical characteristics of SiNWs were measured by FT-IR spectroscopy and indicated that the surface of SiNWs are terminated with hydrogen. The thicknesses and lengths of SiNWs are typically 150-250 nm and 2 to 5 microns, respectively.

Structure-based drug design possibly benefit from in silico methods that precisely predict the binding affinity of small molecules to target macromolecules. There are many limitations arise from the difficulty of predicting the binding affinity of a small molecule to a biological target with the current scoring functions. There is thus a strong interest in novel methodologies based on MD simulations that claim predictions of greater accuracy than current scoring functions, helpful for a regular use designed for drug discovery in the pharmaceutical industry. Herein, we report a short review on free energy calculations using MMPBSA method a useful method in structure based drug discovery.

District of Korea affected by westerly wind and heavy rainfall is predominantly distributed in the west and south of Honam district. So, this study is becoming a necessity. In this study, it is investigated that the characteristics of heavy rainfall occurred frequently in Honam district along the border of mT airmass after the end of rainy season due to atmospheric instability, lower (850 hPa) convergence and topographic effect. Our results show that heavy rainfall occurred in Honam district along the border of mT airmass results from the appropriate mechanism of the unstable vertical structure and moisture flux in the expansion and contraction of the border of mT airmass. All things considered, the improvement of the predictability of heavy rainfall occurred in Honam district along the border of mT airmass could be possible by the generalization of the results of this study.

The pharmaceutical industry has an ongoing need for new, safe medicines with genuine biomedical effects. Most of the candidate molecules are far from becomes a drug, because of their pharmacokinetic and pharmacodynamic properties. The introduction of bioisostere to improve properties of molecules and to obtain new class of compound is currently increased. Silicon substitution of carbon of existing drugs is an attractive strategy to search a new candidate with improved biological and physicochemical properties. The fundamental differences between carbon and silicon can lead to improved profile of the silicon containing candidate, and could be exploited to get further benefit in drug design process.

In this study, PEDOT thin films polymerized with Iron(III)tosylate (Fe(PTS)3) and grown on acetic acid-catalyzed 3- aminopropyltriethoxysilane self-assembled monolayer (APS-SAM) surfaces by VPP method have been investigated. PEDOT thin films were synthesized on APS self-assembled SiO2 wafer surface at two different concentrations (20 wt% and 40 wt%) and growth time (3 and 30 minutes), and then they were compared. PEDOT vapour phase-polymerized with 40 wt% Fe(PTS)3 oxidant completely formed a thin film on acetic acid-catalyzed APS-SAM surface while with 20 wt% Fe(PTS)3 did not at all. It means that the oxidant can be uniformly coated on acetic acid-catalyzed APS-SAM surface at the 40 wt% concentration, which gives rise to the uniform growth of PEDOT thin film on it.

In this study, PEDOT thin films polymerized with Iron(III)tosylate (Fe(PTS)3) and grown on atomically smooth and highly dense 3-aminopropyltriethoxysilane self-assembled monolayer (APS-SAM) surfaces by VPP method have been investigated. PEDOT thin films were synthesized on APS self-assembled SiO2 wafer surface at two different concentrations (20 wt% and 40 wt%) and growth time (3 and 30 minutes), and then their sheet resistance were measured and compared. PEDOT thin films grown with 20 wt% Fe(PTS)3 oxidant are highly conductive when compared with the film grown with 40 wt% Fe(PTS)3, as ascertained by the measured sheet resistance values down to 0.06 Ω/cm. It clearly suggests that 20 wt% is more effective oxidant concentration for VPP than 40 wt% even though the film grown with 40 wt% oxidant has better quality than the film with 20 wt% Fe(PTS)3 does.

Categorical data collected based on complex sample design is not proper for the standard Pearson multinomial-based chi-squared test because the observations are not independent and identically distributed. This study investigates effects of bias of point estimator of population proportion and its variance estimator to the standard Pearson chi-squared test statistics when the sample is collected based on complex sampling scheme. This study examines the effect under two population homogeneity test. The standard Pearson test statistic can be partitioned into two parts; the first part is the weighted sum of ?? with eigenvalues of design matrix as their weights, and the additional second part which is added due to the biases of the point estimator and its variance estimator. Our empirical analysis shows that even though the bias of point estimator is small, Pearson test statistic is very much inflated due to underestimate the variance of point estimator. In the connection of design-based variance estimator and its design matrix, the bigger the average of eigenvalues of design matrix is, the larger relative size of which the first component part to Pearson test statistic is taking.

Multivariate cumulative sum (CUSUM) control charts for simultaneously monitoring both means and variances under multivariate normal process are investigated. Performances of multivariate CUSUM schemes are evaluated for matched fixed sampling interval (FSI) and variable sampling interval (VSI) features in terms of average time to signal (ATS), average number of samples to signal (ANSS). Multivariate Shewhart charts are also considered to compare the properties of multivariate CUSUM charts. Numerical results show that presented CUSUM charts are more efficient than the corresponding Shewhart chart for small or moderate shifts and VSI feature with two sampling intervals is more efficient than FSI feature. When small changes in the production process have occurred, CUSUM chart with small reference values will be recommended in terms of the time to signal.

The rugate porous silicons containing multiple photonic band gaps have been generated by applying a composite waveform summed three computer-generated pseudo-sinusoidal current waveforms and exhibit three sharp photonic band gaps in the optical reflectivity spectrum. Generated multiple rugate porous silicons display three rugate peaks corresponding to the each of the sine components varied from 0.42, 0.36, and 0.30 Hz, with a spacing of 0.06 Hz between each sine component. The resulting rugate PSi films have been removed from the silicon substrate by applying an liftoff current and are then made into particles by ultrasono-method in a organic solution. The sensing experiments using these particles for organic solvents such as toluene, hexane, acetone, and methanol have been achieved. Condensing of organic vapors in the pores increases the refractive indices of entire particle which results a red shift in the photonic peaks.