Earticle

This study explores the parallel and serial relations among linguistic categories and their cognitive interface patterns. By analyzing the proximity between categories as well as serial and parallel propositions, the research reveals the interface mechanisms between different cognitive domains. It finds that categories within the same cognitive domain form complex networks through cross-connections, while metaphorical and metonymic interfaces extend the semantic boundaries of categories. The innovation of this study lies in proposing the concept of the “interface domain,” deepening the understanding of the mechanisms behind linguistic categorization and revealing category relations across multiple languages. Furthermore, the study identifies two primary types of interface relations: metaphorical and metonymic, highlighting their distinct roles in category formation and cross-domain mappings. Through an analysis of the Chinese character “大”(big), the research illustrates how categories interface across dimesions such as space, intensity, status, and degree. It also compares these patterns with English equivalents, revealing significant cultural and cognitive differences in categorization paths.

본 연구는 한국 교정시설의 심리치료프로그램에 참여한 128명의 고위험 남성 성범죄자들을 대상으로 실시되었다. 이들을 연쇄 성범죄자(n= 63)와 비연쇄 성범죄자(n= 65)로 구분해 MMPI-2 반응에서의 차이를 비교하였다. 판별분석을 통해 두 집단을 구분하는 MMPI-2 척도가 무엇인지 확인하고자 하였다. MMPI-2의 모든 척도(예: 타당도 척도, 임상 척도, 재구성 임상 척도, 성격병리 5요인 척도, 임상 소척도, 내용 척도, 내용 소척도, 보충 척도)와 하위 척도를 검토했다. 그 결과 재구성 임상 척도, 성격병리 5요인 척도, 임상 소척도, 내용 소척도가유의한 판별 모델을 구성했다. 분류 정확도는 각각 67.9%, 64.8%, 78.1%, 78.9%로 나타났다. 두 집단을 구분한 중요한 하위 척도는 낮은 긍정 정서(RC2), 의기소침(RCd), 피해의식(RC6), 정신증(PSYC), 내향성/낮은 긍정적 정서성(INTR), 둔감성(D4), 깊은 근심(D5), 자기 회의(LSE1), 낮은 동기(TRT1), 동기 결여(DEP1) 및 자살 사고(DEP4)였다. 연쇄 성범죄자들의 평균 점수가 비연쇄 성범죄자들보다 높았다. 결론적으로 연쇄 성범죄자들은 비연쇄 성범죄자들에 비해 더 부정적 사고를 하고 우울한 경향이 있는 것으로 나타났다. 마지막으로 연구의 의의및제한점에대해논의하였다

This research was conducted on 128 high-risk male sex offenders who participated in the psychotherapy program of a Korean prison. We compared differences in MMPI-2 responses by separating them into serial sex offenders (n= 63) and nonserial sex offenders (n= 65). We used discriminant function analysis to identify the MMPI-2 scales that distinguished the two groups. We reviewed all MMPI-2 scales and subscales and found that the RC scales, PSY-5 scales, clinical subscales, and content component scales constituted a significant discriminant function model. Classification accuracy was 67.9%, 64.8%, 78.1%, and 78.9%, respectively. The significant subscales that distinguished the two groups were low positive emotions (RC2), demoralization (RCd), ideas of persecution (RC6), psychoticism (PSYC), introversion/low positive emotionality (INTR), mental dullness (D4), brooding (D5), self-doubt (LSE1), low motivation (TRT1), lack of drive (DEP1), and suicidal ideation (DEP4) scales. The mean score of serial sex offenders was higher than that of non-serial sex offenders. In conclusion, serial sex offenders tend to be more negative thinking and depressed than non-serial sex offenders. Finally, the implications and limitations of this research are discussed.

이 연구는 체육특기자 학사관리에 대한 미디어의 보도행태와 역할 분석을 시도하였다. 이를 위하여 네이버 신문 기사 검색을 통해 체육특기자 학사관리 보도에 적극적인 9개 신문을 선정하였다. 검색 주제어는 ‘체육’, ‘특기’, ‘학사’, ‘관리’였으며, 시간적 분석범위는 2016년 9월 13일부터 2017년 4월 9일까지로 총 148건을 분석하였다. 분석방법은 발행된 신문의 제목과 내용에 대하여 시계열적이고 해석적인 내용분석을 실시하였다. 시간의 흐름 따른 이벤트는 총 16 개로 나눠지고 국면은 4개로 범주화 되었다. 첫째, 놀람, 의혹의 범주. 둘째, 분노, 실태파악의 범주. 셋째, 문제의 심화, 사회적 요구 범주. 넷째, 사회변화의 흐름 범주로 확인되었다. 내용에 관한 질적 분석결과로는 양적인 집중과 사회집단 의 집중화 논조가 확인되었다. 본 분석에서 미디어는 다양한 이익관계자의 요구를 균형감 있게 다루었으며, 빠른 의견조 율과 정책수용과정을 유도하였다는 결론을 도출하였다.

This study attempted to make a roll and press behavior analysis for the major newspapers' coverage at academic managing system for student athlete. To this end, nine major newspapers with the most subscription were selected by pre searching in Naver Newspaper provide. The search key words were ‘sport’, ‘athlete’ and ‘academic’ and ‘management’, a total of 148 articles were analyzed from April 13, 2016 to April 9, 2017. The Time serial interpretive textual analysis method was employed to analyze the text meanings and implications of newspaper headlines and article. According to time serial text analysis, the phases were classified into 4 categories and the event divided into 16. The four phases are as follows: First, surprise, suspicion. Second, anger, real situation grasp. Third, deepening of problems, social demands. Fourth, the flow of social change. As a result of the qualitative analysis of contents, quantitative concentration and coordination of social groups were confirmed in article viewpoint. The media handled the needs of various stake-holders in a balanced way, it led to fast feedback and policy changes.

The Serial murder is a serious social phenomenon that gives a shock to community and society, because of it's habituate and scheme. We could identify a happening of serial killing crime at Western society, especially in U. S, but hardly to find many cases in Korea except some of cases. We can easily prospect the happening of serial killing crime at Korea in the future, at least it exists that home and social disorganization cause by divorcing and hasty economic development. There will be a reserve criminal who have distorted personality effected by undesirable surrounding, therefore he may become a serial murder. This study examines criminal psychological analysis of On Bo Hwan's serial murder case in 1994 at Korea, according to criminal records and press report and his statement and confession. This paper also show his domestic background and growing atmosphere and human relation between his parents.

최근 연쇄강력범죄가 증가하면서, 일반적인 수사기법으로 해결하기 어려운 사건들이 빈발하고 있다. 이로 인해 시민들의 불안이 증가하고, 경찰의 수사능력에 대한불신도 높아지고 있다. 점점 교묘화, 흉포화, 지능화되어가는 범죄양상에 효율적으로 대처하기 위하여 과학적 수사역량이 더욱 필요한 실정이다. 선진 각국경찰에서는 범죄자 유형분석기법(Criminal Profiling), 지리학적 프로파일링(Geographic Profiling)기법 등을 연쇄강력범죄 수사에 활용하여, 범인의 주거지를 압축하는 성과를 거양하고 있다. 특히 지리학적 프로파일링기법은 범죄자가 가장 있을 법한 장소를 예측하고 찾아내고, 일련의 관련된 범죄장소를 분석해내는 수사방법이다. 연쇄살인, 연쇄강간, 연쇄방화, 연쇄폭파사건들을 수사하는 데 있어서 수사관들의 수사에 결정적 단서를 줄 수 있기 위하여 고안된 전략적인 정보관리 시스템 중의 하나이다. 본논문에서는 연쇄강력 범죄자의 주거지(Offender Home, Working Place)와 범행장소간(Crime Scene)에 상관성이 있음에 착안하여, 범행동기, 연령, 범행지속 등에 따른 이동거리의 상관성을 분석하였다.

As serial violent crimes committed by a certain criminals have increased, cases which are difficult to be solved by general investigation methods often occurs these days. Because of this fact, there are growing civil fear and distrust in investigating ability of the police. Therefore more scientific ways of crime investigation are needed to cope with more sophisticated, brutal and intelligent crimes effectively. Geographic profiling is one of crime investigation methods. It analyzes serial crime spots. It's a kind of strategic approaches that helps criminal detectives charge of serial murders, sexual assaults, arsons and bombing cases. This research is about serial violent crimes happened in Korea recently and analyzed according to the geographic profiling method and previous advanced studies from abroad. I dealt with just several cruel cases broadcast nationwide due to the limitation of approaching to the enough basic data. With difficulties of obtaining enough research materials such as data sampling, demography and correct addresses related, I wasn't able to reach perfectly analyzed results. Therefore the more scientific and sophisticated study should be followed.

목적 : 편마비 환자에서 손상된 대뇌반구의 동측은 정상으로 인식되었으나 운동장애가 있음이 보고되고 있다. 본 연구는 편마비 환자의 동측 상지를 이용한 연속반응시간과제에서 동측운동결함 여부를 정상군과 비교 관찰하였다. 연구방법 : 편마비 환자 18명(오른쪽 편마비 10명, 왼쪽 편마비 8명)을 대상으로 손상된 대뇌반구의 동측 손가락을 이용한 연속반응시간과제를 수행하는 동안 환자군과 연령과 성별이 일치하는 정상군 18명과 비교하여 반응시간을 분석하였다. 연속반응시간과제는 구획설계와 무작위설계로 구성하였고 자극은 4가지 색깔(빨강, 노랑, 초록, 파랑)의 원모양이 하나씩 연속적으로 컴퓨터 모니터에 제시되었고, 연구대상자는 일련의 자극과 색깔이 일치하는 반응패드의 버턴을 가능한 빠르고 정확하게 누르도록 하여 반응시간을 측정하였다. 각 설계단위 당 10회 반복하는 것을 1블록으로 설정하여 총 3블록을 수행하였고, 수집된 자료는 이원분산분석으로 통계 처리하였다. 결과 : 구획설계와 무작위설계 모두에서 집단간 주효과 검증결과 집단 간에는 통계학적으로 유의한 차이가 관찰되었다(p<0.001). 그러나 오른손·왼손간 주효과 검증결과 및 집단×왼쪽·오른쪽간 상호작용에는 통계학적으로 유의한 차이가 관찰되지 않았다(p>0.001). 결론 : 환자군에서 연속반응시간과제의 반응시간이 정상군보다 느리게 나타나 편측 대뇌반구 손상으로 인한 편마비 환자의 동측 상지에 동측운동결함이 발견되었다.

Objective : Recent several investigations reported that impared motor function were detected on the ipsilateral as well as the contralateral upper extremity of the damaged hemisphere in patients with hemiparetic stroke. We investigated to determined the presence of ipsilateral motor deficits in serial reaction time task, and to infer the possible causes of the deficits. Methods : Eighteen stroke patients(10 right hemiplegia, 8 left hemiplegia) with fist-ever unilateral brain damage and the same number of normal control subjects were recruited, who were matched to sex and age. Subjects were assigned to press the matched button as quickly and accurately as possible, when one of four colored lights was displayed on computer screen(red, yellow, green, blue). We used three randomly order blocks and sequence order blocks respectively as motor paradigm of serial reaction time task. One block consisted of ten units that had ten stimulus. Reaction time was recorded during the tests. Results : A two-way ANOVA showed that there were statistically significant difference in a main effect of group(P<0.001), but not in a main effect of damaged side(P>0.05) and the interaction of group×damaged side(P>0.05) on the tests of random and block task paradigms. And group comparison within each sides of the upper extremities showed significant difference in all of two test(P<0.05) Conclusion : The findings provided by the experimental revealed that patients with unilateral brain damage have subtle deficits of the ipsilateral motor performance in serial reaction time task. We suggest that the ipsilateral upper extremity need to be carefully assessed in hemiparetic stroke patients in clinical neurorehabilitation.

특정 강력범죄자에 의하여 저질러지는 연쇄범죄들이 최근에 증가하면서, 일반적인 수사기법으로 해결하기 어려운 사례가 빈번해졌다. 이로 인하여 시민들의 범죄에 대한 두려움, 형사사법기관에 대한 불신이 점증하고 있다. 교묘화, 흉포화 그리고 더욱 복잡해진 사건에 대하여 과학적 수사기법을 활용한 사건해결 노력이 긴요시 되고 있다. 본 연구는 지리적 프로파일링 기법 및 국내외 선행연구결과를 토대로 한국에서 최근 수년 동안에 발생한 연쇄강력범죄를 분석한 것이다. 지리적 프로파일링 기법은 연쇄살인, 연쇄강간 및 방화 등의 범죄현장을 분석하여, 용의자의 주거지 혹은 생활근거지 추정을 도와줌으로써 용의자 체포에 상당한 도움을 제공할 수 있는 전략적 접근이다. 본연구를 수행하는 과정에서 자료수집에 많은 어려움이 있었는바, 언론에 보도되어 그 범죄정황이 소상하게 밝혀진 대표적 사례들만을 주로 활용하였다. 연쇄강력범죄의 범행동기에 따라서 범죄자의 이동특성이 확연하게 구별된다는 것을 확인할 수 있었으며, 범행이 지속될수록 주거지 쪽으로 근접하는 경향성을 또한 확인하였다. 향후 보다 정확한 분석을 위해서는 많은 자료들을 대상으로 정교하고 과학적인 후속연구가 진행되어야 할 것이다.

As serial violent crimes committed by a certain criminals have increased, cases which are difficult to be solved by general investigation methods often occur these days. Because of this fact, there are growing civil fear and distrust in investigating ability of the police. Therefore more scientific ways of crime investigation are needed to cope with more sophisticated, brutal and intelligent crimes effectively. Geographic profiling is one of the crime investigation methods. It analyzes serial crime spots. It is a kind of strategic approaches that help criminal detectives charge of serial murders, sexual assaults, arsons and bombing cases. This research deals with serial violent crimes happened in Korea recently and analyzes the spatial characteristics of serial violent crimes according to the geographic profiling method and previous advanced studies from abroad. Due to the limitation of approaching to the enough basic data, just several cruel cases broadcast nationwide were dealt with. With difficulties of obtaining enough research materials such as data sampling, demography and correct addresses related, this analysis was not perfectly reached. Therefore the more scientific and sophisticated study should be followed.

We report a case on the comprehensive application of forensic science and criminal profiling for capturing a serial rapist. Since June 2001 a rapist from Chungnam Province (the west coast area) committed at least 8 rapes. The frequency of the CODIS core STR profile identified was estimated to be 4.44 x 10-18. Crime scene aspects of a serial rapist show similar components in the viewpoint of geographical and behavioural characteristics. 17 Y-STR haplotype of the biological materials left at eight serial crime scenes was carried a star-like cluster from a specific surname in Korea population data [Forensic Sci. Int.: Genetics 5(2011), e122- 123]. In societies, patrilineal surnames and Y-STR haplotypes are expected to be correlated. This characteristic could help defining an initial pool of suspects in forensic routine by the analysis of biological material left at the crime scene and evaluating the haplotype correlated. It was expected as a suspect with common surname living the west coast area of Chungcheong district by the application of efficient methods. We suggest the comprehensive application including forensic DNA analysis and criminal profiling could lead to trace felonious criminals in forensic investigations on a much wider scale than has been used to date.

본 연구에서는 1980년대부터 2000년대에 이르기까지 기록관리학 연구영역에 대하여 수행된 총 12건의 연구들을 시계열적으로 분석하였다. 분석결과, 1980년대의 기록관리학 연구들은 주로 기록물과 기록관을 중심으로 수행되었으며, 1990년대에는 전자기록물의 급증과 함께 그 연구영역이 정보시스템 및 사회 환경으로 확장된 것으로 나타났다. 2000년대에는 디지털 환경에서 파생되는 여러 전문적 정보기술 주제와 함께 인접 학문과의 결합성이 더욱 강조되는 학제적 연구주제들이 제기되고 있으므로 향후 기록관리학 연구영역의 확장 가능성을 확인할 수 있었다.

In this study, twelve research papers on “records management and archives research areas" that were written from the 1980s to the 2000s were analyzed according to a timeline. The results show that the main subject areas during the 1980's were records and archives. During the 1990s, with the increase of electronic records, research areas expanded to information systems and related social environments. In the 2000s, more advanced technical and interdisciplinary subjects have emerged in the digital society. These results show that research areas in records management and archives still have much potential for growth and will expand in the near future.

한국에서 연쇄살인은 1970년대부터 2020년대에 이르기까지 지속적으로 발생하고 있으며, 일반인 에게 큰 두려움을 유발하고 있다. 1970년대 이래 연쇄살인에 대한 다양한 연구가 이루어지고 있는 미국과 달리 우리나라의 학계에서는 많은 연구가 이루어지지 않고 있으나, 다수의 소중한 생명을 영 구적으로 말살하는 연쇄살인은 그 사회적 해악성이 매우 큰 범죄이기 때문에 이에 대한 다양한 연 구가 필수적으로 요구되는 바이다. 이에 이 연구에서는 살인 및 연쇄살인의 개념, 선행 연구들을 살펴보고 한국의 주요 연쇄살인 사 례를 검토한 후 이를 Holmes와 DeBurger(1985)가 제시한 연쇄살인범의 범행동기에 따른 분류체계 를 기반으로 하여 유형별로 제시하였다. 한국의 주요 연쇄살인범 사례에서는 1970년대부터 2000년에 이르는 대표적 연쇄살인범 15건을 살 펴보았다. 이 사례들을 연쇄살인범의 동기유형별 범죄현장 분석을 바탕으로 하여 연쇄살인범의 유형 을 고찰하였다. 한국의 연쇄살인범을 범죄현장분석을 바탕으로 하여 동기유형별로 살펴본 결과 가장 많은 유형은 스 릴형(자극추구형)이었고 사명형, 권력형, 위안형(금전추구형) 등의 순으로 드러났다. 환청, 환각, 환영 등 의 지시에 따라 사람을 살해하는 유형인 망상형 연쇄살인범은 이번 연구결과에서는 나타나지 않았다. 이번 연구의 범죄현장 분석은 공개된 자료를 바탕으로 하였기 때문에 공개되지 않거나 밝혀지지 않은 내용은 반영하지 못한 한계가 있으나, 그 동안 주관적으로 이루어진 한국의 연쇄살인범에 대한 유형화를 처음으로 객관적 기준을 바탕으로 분류하여 향후 이루어질 한국의 연쇄살인 연구 및 수사 에 선험적 가이드라인이 되기를 기대한다.

Serial murders have occurred continuously in Korea from the 1970s to the 2020s, causing great fear in the general public. Unlike in the United States, where various studies on serial murder have been conducted since the 1970s, not much research has been conducted in Korean academic circles. However, serial murder, which permanently destroys many precious lives, is a crime with great social harm, so there is need to research it. Accordingly, in this study, I looked at the concepts of serial murder and previous studies, reviewed major serial murder cases in Korea, and categorized them into types based on the classification scheme according to the crime motive of serial murderers presented by Holmes and DeBurger(1985). In the case of major serial murders in Korea, we looked at 15 representative serial murderers from the 1970s to 2000. In these cases, the types of serial murders were examined based on crime scene analysis by type of serial murderer's motive. As a result of examining Korean serial murders by motive type based on crime scene analysis, the most common type was thrill-seeking type, followed by mission-oriented type, power/control-oriented type, and comfort(money-seeking) type. Visionary type serial murders were not found in the results of this study. Because the crime scene analysis in this study was based on publicly available data, there are limitations in not reflecting undisclosed or hidden contents. However, for the first time, the subjective typification of serial murders in Korea was based on objective standards. I anticipate that the classification will serve as an a priori guideline for future serial murder research and investigation in Korea.

본 연구는 연쇄강간 사건에 다양한 지리적 프로파일링 방법을 적용시켜 지리적 프로파일링 기법의 유용성을 확인하고, 보다 효과적인 기법을 확인하기 위한 목적으로 이루어졌다. 이를 위해, 경찰청 지리적 프로파일링 시스템과 CrimeStat 3.0을 사용하여 최소 거리 중심, 평균중심, 수학적 거리 감퇴함수 등과 같은 지리적 프로파일링 분석 알고리즘에서 예측된 범인의 거주지와 검거 후 확인된 연쇄 강간범의 실 거주지 위치 값을 비교하였다. 연구 결과, 범죄자의 심리적 완충지역과 범행이 증가할수록 범인의 실 거주지에서 범행 발생 지역 거리가 증가한다는 거리감퇴 모델을 가정하는 로그정교함수와 절삭된 부적지수 함수의 정확도가 상대적으로 높게 나타났다. 특히, 범죄자의 완충지역이 상대적으로 넓게 분포하는 로그정규함수를 통한 연쇄 강간범의 거주지 예측 결과의 정확도가 가장 높게 나타나, 국내 연쇄강간범들이 자신의 주거지 인근 지역을 벗어난 외부 주변지역에서 주로 범행을 한다는 사실을 확인할 수 있었다. 한편, 최근거리평균 등과 같은 공간 통계 방법의 경우 강간범죄의 연쇄 건수에 의존적으로 발생건수가 극단적으로 적거나 많은 경우에는 수학적 함수를 통한 분석 결과에 비해 정확도가 감소하는 경향을 보였다. 본 연구는 실제 사건 자료를 토대로 지리적 프로파일링을 위한 공간 통계 분석을 시도했다는 점에서 의의가 있다. 특히, 완충지역과 거리감퇴 모델이라는 이론적 틀 안에서 적용되는 수학적 함수들과 단순거리 평균값의 정확도를 비교 분석한 연구 결과는 실무 차원에서 보다 효율적인 지리적 프로파일링 분석 방법을 선택, 활용하는데 도움을 줄 수 있을 것이다.

This study evaluates the usefulness of applying the different geographical profiling methods to serial rapes for eliciting more efficient geographical profiling analysis techniques. Using the Geographical Analysis System by Korean National Police Agency and CrimeStat 3.0, the location of rapists's residence were calculated based on both spatial statistics methods such as center of minimum distance, mean center and mathematically 5 kinds distance decay functions. Comparing with the location of between real and predicted rapists' residence, the results showed that both log-normal function and truncated negative exponential function based on the criminals' psychological buffer zone and distance-decay model was proven by relatively higher accuracy. Noticeably, estimate on suspect's residence using log-normal function assumed larger psychological buffer zone was highly accurate, showing that domestic serial rapists commit their crime outside of their residential area. As per spatial statistics such as center of minimum distance, mean center, it was found that analysis results based on mathematical functions became less accurate for extreme frequencies of serial rapes. This research is meaningful in the sense that it attempted statistical analysis based on the actual cases for geographical profiling. Moreover, its results in comparing the accuracies between mathematical functions and simply spatial statistics in the theoretical frame will facilitate more efficient selection of investigation tool in the scenes.

For the comprehensive analysis of transcript ex-pression, the array-based hybridization analysis and the serial analysis of gene expression (SAGE) on a high-throughput sequencing of ditags derived from the transcript. DNA microarays are a power-ful tool for monitoring thousands of transcripts simultaneously, whereas the Genechip (Afimatrix microaray) technology is based on the hybridi-zation of a single probe or other manufacturer's microarays (cDNA- or oligonucleotide-microaray) procedures include the competitive hybridization of two probes. In this study, the quantitative acuracy of expresion using oligonucleotide-mi-from the SAGE. In previous study the microSAGE was performed for the megakaryocytes and non- megakaryocytes derived from human cord blod CD34+ cells by ex vivo expansion using thrombo-poietin, and a total of 38,909 tags representing 8,976 unique genes were obtained. On the iden-tical RNA, expresion profiling was also caried out using oligonucleotide-microaray (MAGIC II 10K chip, Macrogen). The most frequently express-fied as platelet factor 1 folowed by annexin A1, ribosomal protein S23. The majority of the 50 most highly expresed genes in the CD34+-derived me-gakaryocytes were those involved in protein syn-thesis, e.g., ribosomal proteins. The expresion level through the single chanel of oligonucleo-tide-microaray and SAGE have a fairly good cor-relation in terms of absolute analyses and that the corelation is higher for the genes with higher ex-pression levels.

To diagnose acute myocardial infarction (MI), many cardiac markers have been used in hematologic and biochemical analysis, and many studies have been published for hematologic and biochemical analysis associated with human acute MI. However, after occurrence of acute MI, the serial investigation for values in hematologic and biochemical analysis including chronic MI has rarely been performed. To observe the change of the serial values in hematologic and biochemical analysis, we induced artificial MI. The left main descending artery (LMDA) of the left coronary artery was ligated during the progression (day 1, 3, 5, 7, 14 and 30) of MI. Total 66 Sprague-Dawley rats were divided into the sham group (n=24, thoracotomy without LMDA ligation) and the experimental (MI) group (n=42, with LMDA ligation). And all individual in each group was sacrified at day 1, 3, 5, 7, 14 and 30 for the hematologic and biochemical analysis. In comparison of hematologic analysis between the sham and MI groups, the mean values of red blood cell (RBCs), hemoglobin and hematocrit (HCT) showed a steady increase. In biochemical analysis, the mean values of glucose, cholesterol, total creatine kinase (CK) and isoenzyme MB, and lactate dehydrogenase (LDH) were increased in all MI groups compared with the sham groups. The results of this study suggest that early hematologic and biochemical mean values occurred after acute MI are similar to those of human acute MI. In conclusion, we could observe the alterations and serial values in hematologic and biochemical analysis to the extent of chronic status after acute MI.

Background/Aims: The aim of this study was to assess the effects of a usual dose of simvastatin (20 mg/day) on plaque regression and vascular remodeling at the peri-stent reference segments after bare-metal stent implantation. Methods: We retrospectively investigated serial intravascular ultrasound (IVUS) findings in 380 peri-stent reference segments (184 proximal and 196 distal to the stent) in 196 patients (simvastatin group, n = 132 vs. nonstatin group, n = 64). Quantitative volumetric IVUS analysis was performed in 5-mm vessel segments proximal and distal to the stent. Results: IVUS follow-up was performed at a mean of 9.4 months after stenting (range, 5 to 19 months). No significant differences were observed in the changes in mean plaque plus media (P&M) area, mean lumen area,and mean external elastic membrane (EEM) area from post-stenting to follow-up at both proximal and distal edges between the simvastatin and non-statin group. Although lumen loss within the first 3 mm from each stent edge was primarily due to an increase in P&M area rather than a change in EEM area, and lumen loss beyond 3 mm from each stent edge was due to a combination of increased P&M area and decreased EEM area, no significant differences in changes were observed in P&M, EEM, and lumen area at every 1-mm subsegment between the simvastatin and non-statin group. Conclusions: A usual dose of simvastatin does not inhibit plaque progression and lumen loss and does not affect vascular remodeling in peri-stent reference segments in patients undergoing bare-metal stent implantation. (Korean J Intern Med 2010;25:356-363)