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This study used data from traditional medicine laws of North Korea, the prologue of the journal Koryo Medicine, and Rodong News to analyze research trends and technological levels of North Korean traditional medicine. This study analyzed the traditional medicine laws of North Korea, the prologue of the journal Koryo Medicine, and Rodong News to obtain data on policy systems and research trends. According to the analysis, the role of Koryo medicine is clearly defined by law as a medical care provider, pharmaceutical production, science and technology development, and herbal preservation. Under Kim Jong Un, Koryo medicine policies have emphasized the commercialization, standardization, and industrialization of Koryo medicine extracts. The results show North Korea’s emphasis on using Koryo medicine and increasing medical independence through Koryo medicine.

This study introduces a Korean Medicine (KM) case using the Practice-Based Research Network (PBRN). We reviewed the registry of herbal decoction for weight loss using the PBRN, as well as the process of building the registry, challenges faced, and achievements. The registry building process using the PBRN included the following: introduction of research outlines to core members; consultation on how to increase its feasibility in KM clinics; surveys on the interest towards the topic among KM doctors (KMDs); development and dissemination of card news on the research; appointment of PBRN members; and education. The major challenge was to increase participation among KMDs. It is important to appoint core members who have networks and experience with clinical research as PBRN members. Consulting with core members on how to increase the feasibility of PBRN in KM clinics could increase the participation rate among KMDs.

This study aims to design and develop the self-monitoring contents and Person Generated Health Data report for the postpartum management group. So far, many mobile apps and wearable health devices for personal health data have been released. However, few services manage postpartum management groups’ health based on Korean medicine knowledge. Our postpartum PGHD report proposed in this paper reflects the clinical indicators of Korean medicine and the actual postpartum record pattern. It provides information to users based on categories of related PGHD items. When the PGHD platform provides this report information, the user can easily interpret PGHD items and monitor their health status integrated compared to the existing simple list-type record information check. In addition, category-specific information based on oriental significance indicator analysis data can be used to connect with oriental medicine treatment in the postpartum management group. In the future, it will be able to contribute to the oriental medical treatment of the postpartum management group if this postpartum PGHD report can be provided by linking the oriental medicine PHR platform in connection with the oriental clinic medical record chart.

This study aims to review the trend of clinical research on dry eye syndrome using Korean medicine. Studies published after 2010 were selected through three international online databases (PubMed, Cochrane Library, CNKI) and two domestic online databases (Science on, OASIS). Only clinical researches were selected and analyzed with the research method. A total of 19 studies related to dry eye treatment were conducted for the past ten years. Acupuncture and herbal medicine were the most frequently used treatment methods. Evaluation tools to measure the patients’ improvement were SIT (Schirmer I test), OSDI (Ocular Surface Disease Index), and BUT (Tear film break-up time). Korean medicine had superior therapeutic effects for dry eye syndrome treatment compared to artificial tear treatment, and the most frequently used treatment method was acupuncture treatment.

Purpose: In this study, the neuroprotective effect of the methanol extract of Daphne genkwa Flos (DGF-ex) against glutamate-induced neurotoxicity was studied in mouse hippocampal HT22 cells. Materials and Methods: We conducted the cytoprotective effect of DGF-ex against a 24-hour-stress-induced condition by glutamate in HT22 cells. The inhibitory effect of DGF-ex on cellular necrosis and apoptosis and ROS (reactive oxygen species) was observed using fluorescence microscopy. To further clarify its antioxidant efficacy, assays on SOD (superoxide dismutase) regulation and DPPH/ABTS radical scavenging ability were also conducted. A chemical profile of DGF-ex was also obtained via UPLC analysis. Results: Pretreatment with DGF-ex significantly reduced glutamate-induced loss of cell viability and release of LDH (lactate dehydrogenase). DGF-ex showed similar effects to the antioxidant quercetin (15μM) in the evaluation of DPPH/ABST radical scavenging activity and SOD activity evaluation. In addition, DGF-ex remarkedly downregulated the glutamate-induced programmed HT22 cell death, which was shown in the normalization of the cellular necrosis and apoptosis ratio. Conclusion: These results exhibit DGF-ex has the ability to protect against glutamate-induced cytotoxicity in the HT22 cell line via the drug candidate’s antioxidant capacity. This research confirmed the DGF-ex as a valuable drug candidate for the prevention and treatment of oxidative stress-mediated neurodegenerative diseases.

This study aims to describe the big data for medicinal biological resources and to discuss how to use the data. The medicinal biological resources data was constructed by producing and processing the information related to medicinal materials in medicinal biological resources big data center of forest big data platform. The big data center has produced 54 million 168 GB data for 27 datasets of 9 types from 2019 to 2021 and has opened it to the public for free. This study also presents valuable use cases in two fields. The information on medicinal biological resources can be used in personal health management in daily life based on Korean medicine. In addition, it can be used to build a big data platform that analyzes biomedical data by combining the compounds of medicinal materials and existing bio big data in the biomedical fields.

This study is a pilot systematic review on the effectiveness and safety of acupuncture for menstrual headaches. Finally, seven documents were included and analyzed according to the protocol. When comparing the treatment effect with total effectiveness as an outcome variable, we found that acupuncture treatment has a therapeutic benefit compared to Western medicine treatment. In addition, there were no reports of adverse events caused by acupuncture treatment. However, it is difficult to conclude the effectiveness of acupuncture treatment due to the small sample size and a sufficient risk of bias in the included studies.