Earticle

현재 위치 Home
간행물 내 원문 검색
많이 이용된 논문

Issues

Reproductive & developmental biology

간행물 정보
  • 자료유형
    학술지
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 간기
    계간
  • 수록기간
    1977 ~ 2018
  • 주제분류
    농수해양 > 축산학
  • 십진분류
    KDC 527 DDC 636
Volume 42 No 1 (1건)
No
1

Signal Transduction of Equine Follicle-Stimulating Hormone Receptor (eFSHR) by rec-eelFSHβ/α, Natural Porcine FSH, and Natural Human FSH

Munkhzaya Byambaragchaa, Dae-Jung Kim, Myung-Hwa Kang, Kwan-Sik Min

한국동물생명공학회(구 한국동물번식학회) Reproductive & developmental biology Volume 42 No 1 2018.02 pp.1-6

※ 기관로그인 시 무료 이용이 가능합니다.

4,000원

In this study, we analyzed signal transduction by equine follicle-stimulating hormone receptor (eFSHR) on stimulation with recombinant eelFSHβ/α (rec-eelFSHβ/α), natural porcine FSH (pFSH), and natural human FSH (hFSH). cAMP stimulation in CHO-K1 cells expressing eFSHR was determined upon exposure to different doses (0-1450 ng/mL) of these hormones. The EC50 value of rec-eelFSHβ/α was 53.35 ng/mL. The Rmax values of rec-eelFSHβ/α and pFSH were 28.12 and 2.88 ng/mL, respectively. The activity of rec-eelFSHβ/α was much higher than that of natural pFSH. However, signal transduction in CHO PathHunter Parental cells expressing eFSHR was not enhanced by stimulation with natural hFSH. Thus, rec-eelFSHβ/α was completely active in cells expressing eFSHR. However, natural hFSH did not invoke a signal response in cells expressing eFSHR. Particularly, natural pFSH was weakly active in the same cells. These results showed that eelFSHβ/α has potent activity in cells expressing eFSHR. Thus, rec-eelFSHβ/α may efficiently bind to eFSHR, where as natural hFSH does not bind to eFSHR.

 

0개의 논문이 장바구니에 담겼습니다.

구매 불가 논문

    선택하신 파일을 압축중입니다.
    잠시만 기다려 주십시오.

    다운로드 불가 논문
    페이지 저장
    소속기관 조회
    이용자님의 소속기관(단체)이 서비스에 가입되어 있는지 확인해 보십시오.
    기관회원에 소속되어 있는 이용자는 원문을 무료로 이용할 수 있습니다.