Earticle

To get the time response characteristics of the hydrostatic transmission, seaborne winch is modelde by using bond graphs. After modeling of its basic elements, it is represented as power flow, and the determination of variable causality. The state equations are derived by using CAMP. As dynamic stabilites and solutions are investigated by perturbation method and direct integration, winch system is stable. Simulations are performed under the conditions of low speed, high speed, and maximum tension. The pressure and flow rate of the hydrostatic transmission have a big overshoot. But when it is comparaed to the empirical data with simulation results, it is similar to each other. When a lead compensator is applied to improve response characteristics of the hydrostatic transmission, rise time and overshoot of the system are improved.

This paper describes interactive computer procedures for design the forming sequences in cold forging. This system is implemented on the personal computer and its environment is a commercial AutoCAD system. The programming language. AutoLISP, was used for the configuration of the system. Since the process of metal forming can be considered as a transformation of geometry, treatment of the geometry of the part is a key in process planning. To recognize the part section geometry, the section entity representation, the section coordinate-redius representation and the section primitive geometru were adopted. This system includes six major modules such as input module, forging design module, forming sequence design module, die design module, FEM verification module and output module which are used independently or in all. The sequence drawing wigh all dimensions, which includes the dimensional tolerances and the proper sequence of operations, can generate under the environment of AutoCAD. The acceptable forming sequences can be verified further, using the FE simulation.

Based on train traction calculation theories, this research first simulates the transports of a typically formed freight train hauled by representative types of freight locomotives in China. Accordingly, the exact change of the traction energy cost intensity of the train in the effect of its inter-stop transport distance is analyzed in a quantificational way for different target speeds. It is found that the inter-stop transport distance of a freight train should be no shorter than 20.00 kilometers in order to decrease the traction energy cost per unit transport especially for a relatively high target speed. As a result, it is suggested that the railway freight transport work ought to try its best to utilize a heavy load train in view of its average inter-stop transport distance of the whole trip and its comparatively energy-saving target speeds. Furthermore, as for the transport operation of a railway network, the requirements to the time of each transport work of a train and so on should also be considered for its traction energy saving in an integrated manner.

Three-dimensional (3D) computed tomography image models are helpful in reproducing the maxillofacial area; however, they do not necessarily provide an accurate representation of dental occlusion and the state of the teeth. Recent efforts have focused on improvement of dental imaging by replacement of computed tomography with other detailed digital images. Unfortunately, despite the advantages of medical simulation software in dentofacial analysis, diagnosis, and surgical simulation, it lacks adequate registration tools. Following up on our previous report on orthognathic simulation surgery using computer-aided design/computer-aided manufacturing (CAD/CAM) software, we recently used the registration functions of a CAD/CAM platform in conjunction with surgical simulation software. Therefore, we would like to introduce a new technique, which involves use of the registration functions of CAD/CAM software followed by transfer of the images into medical simulation software. This technique may be applicable when using various registration function tools from different software platforms.

Three-dimensional (3D) computed tomography image models are helpful in reproducing the maxillofacial area; however, they do not necessarily provide an accurate representation of dental occlusion and the state of the teeth. Recent efforts have focused on improvement of dental imaging by replacement of computed tomography with other detailed digital images. Unfortunately, despite the advantages of medical simulation software in dentofacial analysis, diagnosis, and surgical simulation, it lacks adequate registration tools. Following up on our previous report on orthognathic simulation surgery using computer-aided design/computer-aided manufacturing (CAD/CAM) software, we recently used the registration functions of a CAD/CAM platform in conjunction with surgical simulation software. Therefore, we would like to introduce a new technique, which involves use of the registration functions of CAD/CAM software followed by transfer of the images into medical simulation software. This technique may be applicable when using various registration function tools from different software platforms.

Nervous necrosis virus (NNV) is a deadly infectious disease that affects several fish species. It has been found that the NNV utilizes grouper heat shock cognate protein 70 (GHSC70) to enter the host cell. Thus, blocking the virus entry by targeting the responsible protein can protect the fishes from disease. The main objective of the study was to evaluate the inhibitory potentiality of 70 compounds of Azadirachta indica (Neem plant) which has been reported to show potential antiviral activity against various pathogens, but activity against the NNV has not yet been reported. The binding affinity of 70 compounds was calculated against the GHSC70 with the docking and molecular dynamics (MD) simulation approaches. Both the docking and MD methods predict 4 (PubChem CID: 14492795, 10134, 5280863, and 11119228) inhibitory compounds that bind strongly with the GHSC70 protein with a binding affinity of -9.7, -9.5, -9.1, and -9.0 kcal/mol, respectively. Also, the ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of the compounds confirmed the drug-likeness properties. As a result of the investigation, it may be inferred that Neem plant compounds may act as significant inhibitors of viral entry into the host cell. More in-vitro testing is needed to establish their effectiveness.

Purpose: To investigate the frequency and clinical significance of detected incidental lung nodules found on computed tomography (CT) simulation images for hepatocellular carcinoma (HCC) using computer-aided diagnosis (CAD) and a physician review. Materials and Methods: Sixty-seven treatment-$na{\ddot{i}}ve$ HCC patients treated with transcatheter arterial chemoembolization and radiotherapy (RT) were included for the study. Portal phase of simulation CT images was used for CAD analysis and a physician review for lung nodule detection. For automated nodule detection, a commercially available CAD system was used. To assess the performance of lung nodule detection for lung metastasis, the sensitivity, negative predictive value (NPV), and positive predictive value (PPV) were calculated. Results: Forty-six patients had incidental nodules detected by CAD with a total of 109 nodules. Only 20 (18.3%) nodules were considered to be significant nodules by a physician review. The number of significant nodules detected by both of CAD or a physician review was 24 in 9 patients. Lung metastases developed in 11 of 46 patients who had any type of nodule. The sensitivities were 58.3% and 100% based on patient number and on the number of nodules, respectively. The NPVs were 91.4% and 100%, respectively. And the PPVs were 77.8% and 91.7%, respectively. Conclusion: Incidental detection of metastatic nodules was not an uncommon event. From our study, CAD could be applied to CT simulation images allowing for an increase in detection of metastatic nodules.

A computer-aided simulation modeling system has been developed to allow the automatic construction of complete discrete simulation models for queueing systems. Three types of knowledge are used in the specification and construction of a simulation modeling: Knowledge of queueing system, simulation modeling, and a target simulation language. This knowledge has been incorporated into the underlying rule base in the form of extraction and construction rule, and implemented via the expert system building tool, OPS5. This paper suggested a knowledge based approach for automatic programming to enable a user who lacks modeling knowledge and simulation language expertize to quickly build executable models.

선로용량은 수요에 부합되는 최대열차횟수를 결정하고 수송력 증대에 필요한 투자우선순위 판단을 위한 중요한 척도이다. 특히 2016년 중반부터 고속철도노선에 두 철도운영자가 운송사업을 개시함에 따라 선로용량과 실제배정 가능한 최대열차횟수 간에 상충이 발생하지 않고 유효운송경쟁이 보증될 수 있도록 선로용량을 산정 관리할 필요성이 있다. 열차종별 운행횟수, 도중정차패턴과 착발시각, 운행시간, 열차의 대피 또는 교행, 열차간의 안전시격 등에 따라 선로용량이 크게 달라지므로 현재까지도 실제 적용에 많은 논쟁이 있는 것도 사실이다. 이러한 문제점을 극복하고자 철도운영자의 운송정책을 고려한 열차운행 스케쥴을 반영할 수 있는 시뮬레이션 기법에 의한 선로용량 산정방법을 제시하고자 한다.

Line capacity of railways is a core criterion to decide maximum trips in accordance with traffic demand and a priority in railway investment to improve transportation capability. Particularly, because two operators will start revenue services in the HSR from mid-2016, the line capacity should be carefully calculated and controlled to avoid conflicts between the maximum number of KTXs, and the number needed to guarantee the effective competition of the operators. Meanwhile, there have been many arguments about calculating the line capacity, because this number is affected by the number of trips by train types, stopping pattern and dwell time in each station, journey time, crossing or passing, safety headway between trains, etc. To deal successfully with these kinds of problems, this study proposes a simulation method to calculate the line capacity that considers train operation according to the operator's service policies.