Earticle

본 논문은 Stability AI의 최신 모델인 Stable Diffusion 3 Medium을 활용하여 고서의 이미지를 생성하는 방법 에 대해 제안한다. 고서의 텍스트를 기반으로 한 이미지 생성 과정에서 Stable Diffusion 3 Medium과 OpenAI 의 DALL-E 모델을 비교 평가하였다. 실험에서는 고서의 원문, 한글 번역문, 영어 번역문을 각각 텍스트 입력으로 사용하여 두 모델의 이미지 생성 결과를 분석하였다. Stable Diffusion 3 Medium은 고서의 내용을 보다 정확히 반영한 이미지를 생성하는 데 있어 우수한 성능을 보였다. 특히, 한글 번역문을 사용한 경우, 고서의 내용을 충실히 반영한 이미지를 생성하였다. 반면, DALL-E는 텍스트의 특정 부분을 강조하여 이미지를 생성하였다. Stable Diffusion 3 Medium은 DALL-E에 비해 보다 일반적인 해석을 통해 이미지를 생성하는 경향이 있었으며, 고서의 시각적 세부 사항을 더 잘 재현하였다.

This paper proposes a method for generating images of historical texts using Stability AI’s latest model, Stable Diffusion 3 Medium. The paper compares the image generation capabilities of Stable Diffusion 3 Medium and OpenAI’s DALL-E model based on the text of historical documents. Experiments involved using the original text, Korean translation, and English translation of the historical document as input for both models, analyzing the results. Stable Diffusion 3 Medium demonstrated superior performance in accurately reflecting the content of the historical texts, particularly excelling with the Korean translation. In contrast, DALL-E highlighted specific parts of the text in its images. Stable Diffusion 3 Medium generally provided a more comprehensive interpretation of the text, better reproducing visual details.

Aminophylline, ceftriaxone 및 ampicillin/sulbactam (Unasyn)을 미숙아용 고영양수액제에 직접 첨가하거나 Y-site로 투여하는 경우의 안정성에 관해 조사하였다. Aminophylline 주사액 (25mg/mL) 와 ceftriaxone sodium (37.5 mg/mL) 2mL를 각각 고영양수액제 직접 첨가하였다. 또한 Y-site에서의 안정성 조사를 위해 ceftriaxone sodium (37.5 mg/mL)을 고영양수액제에 각각 1:1 및 1:2 부피비가 되도록 혼합하였고 Unasyn (25mg/mL)은 고영양수액제와 1:1의 부피비로 혼합하였다. 이상과 같이 조제한 혼합액을 와 에 보관하여 aminophylline은 48시간 동안 그리고 항생제들은 24시간 동안의 경시변화를 HPLC를 이용하여 분석하였다. Aminophylline은 위 보존조건에서 48시간동안 안정하였다(변화율 <). Ceftriaxone sodium을 고영양수액제에 직접 첨가한 경우 ceftriaxone의 잔존률은 에서 4시간째에 이었고 에는 로 측정되었다. Y-site에서의 안정성과 관련하여 ceftriaxone sodium을 고영양수액제와 1:1로 혼합한 경우 양 보존조건에서 ceftriaxone은 24시간 동안 안정하였으나 1:2로 혼합한 경우에는 보관 시에만 안정하였고 에서는 24시간째에 약 정도 분해되는 것으로 나타났다. 한편, Unasyn의 경우 ampicillin은 24시간째에 보관 시에만 안정하였고 에서는 24시간째에 약 정도 분해되는 것으로 나타났다. 한편, Unasyn의 경우 ampicillin은 24시간째에 에서는 안정하였으나 에서는 까지 감소되는 것으로 분석되었고 sulbactam은 24시간째에 온도와 관계없이 안정한 것으로 나타났다. Ceftriaxone sodium을 TPN과 Y-site 혼합 후 1-2시간 이내에 침천이 형성되었고 Unasyn의 경우에는 12시간째에 침천이 형성되었다. 혼합액의 pH나 색상은 연구기간 동안 일정하였다. 이러한 연구결과에 기초할 때, aminophylline은 고영양수액제와 혼합가능하고 ceftriaxone과 Unasyn은 고양양수액제와 혼합시 최소 1시간 동안은 안정한 것으로 평가되었다.

Paclitaxel과 cephalosporines(제 1세대인 ceftezole sodium과 cephradine, 제2세대인 cefamandole sodium과 cefmetazole sodium, 제3세대인 cefoperazone sodium과 cefotaxime sodium 그러고 제4세대인 cefepime hydrochloride)을 포도당주사액 그리고 염화나트륨주사액과 함께 Y-Site 장치를 써서 환자에게 주입할 때 paclitaxel의 안정성에 관하여 연구하였다. Paclitaxel 0.3 mg/ml 및 1.2 mg/ml과 cephalosporines 20 mg/m을 각각 1 : 1로 혼합한 후 0, 1, 2, 4, 12시간 시점에서 paclitaxel의 농도를 HPLC로 분석하였다. 방해물질에 의한 분석오차를 줄이기 위해 분석법을 여러 상태에서 확인하였으며, 각 농도에서 3차례씩 실험하였고 각 샘플은 2차례 반복하여 HPLC로 분석하였다. 분석전에 각 시료의 투명도, 색의 변화, 침전상태 및 pH를 검사하였다. Paclitaxel 0.3 mg/ml 및 1.2 mg/ml와 cephalosporines 20 mg/ml를 각각 혼합하였을 때 12시간 동안 안정하였으며, 주사액의 혼탁이나 색의 변화 및 침전은 나타나지 않았으며 pH도 변하지 않았다.

Paclitaxel과 vancomycin을 포도당주사액, 염화나트륨주사액 또는 하트만용액과 함께 Y-Site 장치를 써서 환자에게 주입할 때 두 약물의 안정성에 관하며 면구하였다. Paclitaxel 0.3 mg/ml 및 1.2 mg/ml과 vancomycin 1 mg/ml, 5 mg/ml 및 10 mg/ml을 각각 1 : 1로 혼합한 후 0, 1, 2, 4, 12시간 시점에서 두 약물의 농도를 HPLC로 분석하였다, 방해물질에 의한 분석오차를 줄이기 위해 분석법을 여러상태에서 확인하였으며 각 농도에서 3차례씩 실험하였고 각 샘플은 반복하여 HPLC로 분석하였다. 분석전에 각 시료의 투명도, 색의 변화, 침전상태 및 pH를 검사하였다. Paclitaxel 0.3 mg/ml 및 1.2 mg/ml와 vancomycin 1 mg/ml, 5 mg/ml 및 10 mg/mt를 각각 혼합하였을 때 12시간 동안 안정하였으며 주사액의 혼탁이나 색의 변화 및 침전은 나타나지 않았으며 pH도 변하지 않았다.

A numerical method for solving Hamiltonian equations is said to be symplectic if it preserves the symplectic structure associated with the equations. Various symplectic methods are widely used in many fields of science and technology. A symplectic method preserves an approximate Hamiltonian perturbed from the original Hamiltonian. It theoretically supports the effectiveness of symplectic methods for long-term integration. Although it is also related to long-term integration, numerical stability of symplectic methods have received little attention. In this paper, we consider explicit symplectic methods defined for Hamiltonian equations with Hamiltonians of the special form, and study their numerical stability using the harmonic oscillator as a test equation. We propose a new stability criterion and clarify the stability of some existing methods that are visually based on the criterion. We also derive a new method that is better than the existing methods with respect to a Courant-Friedrichs-Lewy condition for hyperbolic equations; this new method is tested through a numerical experiment with a nonlinear wave equation.

A dynamic model was set up for the rotor-bearing system with coupling faults of crack and rub-impact. Using the continuation-shooting algorithm for periodic solution of nonlinear non-autonomous system, the stability of the system periodic motion was studied by the Floquet theory. The saddle-node bifurcation, periodic-doubling bifurcation and the Hopf bifurcation were found. There are peculiar dynamic characteristics of the rotor-bearing system with coupling faults of crack and rub-impact that differs from single fault. The conclusions provide theoretic basis reference for the failure diagnosis of the rotor-bearing system with coupling faults of crack and rub-impact fault.

Stability of soybean isoflavone isomers according to extraction conditions such as temperature, pH, and extracting solvents was investigated. Heating induced three chemical reactions to occur for malony1 derivatives of isoflavones, namely decarboxylation of malony1 groups into acety1 derivatives, deesterification of malony1 residues, and hydrolysis of $\beta$-glycosidic bonds. Among the twelve isoflavone isomers, change in concentrations of acety1glycosides were most pronounced: Acety1 derivatives were present only in trace amounts in unheated hypocotyls, but the content increased dramatically during heating. As for the glycosides, concentrations of daidzin and glycitin increased due to heat treatment, though that of genistin remained almost unchanged. Heat decomposition rates and the patterns differed among the three malony1 derivatives. After 120 min at $80^{circ}C$, the relative concentrations of daidzin, glycitin and genistin were increased from $9.2\%$, $12.4\%$ and $3.3\%$ to $19.3\%$, $21.9\%$ and $6.2\%$, respectively. When crude isoflavones were solubilized in glycine buffer (pH 10.0) and incubated at $80^{circ}C$, deesterification occurred faster than at pH 7.0. When the pH of isoflavone solution was increased, the malony1glycosides were hydrolyzed to their respective glycosides at increased rate. Both acetyl and aglycone forms were unchanged and only de-esterification reactions occurred. At the acidic pH, malonylglycosides were much stable both at 60 and $80^{circ}C$. However at pH 10, $80^{circ}C$ and 1 hr, $75-80\%$ of malonylglycosides were transformed to their deesterified glycosides. When isoflavones were extracted with $60\%$ aqueous ethanol at $60^{circ}C$, isoflavone isomers were stable and the deesterification reactions did not occur in these conditions. However, at $80^{circ}C$ deesterification of malonyiglycosides occurred significantly with $15-20\%$ of malonylglycosides being hydrolyzed into their respective glycosides. This experiment showed that malonylglycosides undergo decomposition when heated or exposed to alkaline conditions. Also, aqueous ethanol was preferred to aqueous methanol as solubilizing media for obtaining extract with minimum degradation of malonylglycosides.

Abstract Purpose: Opinions for stability of carboplatin in chloride containing solutions is controversial. This study was conducted to evaluate the stability of carboplatin in normal saline that was representative chloride containing solutions used for dilution of chemotherapeutic agents. Whether initial dilution concentration and storage time were effect factors on carboplatin decreasing rate were also assessed. Methods Dilutions of carboplatin 0.3, 0.5, and 1.0 mg /ml were prepared in normal saline. Aliquots of each solution were transferred to glass containers for storage at room temperature for 24hours. Samples of each solution were analyzed for carboplatin concentration decreasing rate initially and at 10, 12, 24 hours after preparation by high performance liquid chromatography. We compared the decreasing rate of each samples according to initial dilution concentration and storage time. For all these measures, multiple comparisons between samples were made with repeated measured ANOVA. Results Carboplatin was compatible with normal saline. During experimental period carboplatin decreasing rate was under 5% and this value was accepted as stable by Korean regulatory standard. When carboplatin decreasing rate of each samples were compared within same initial dilution concentration, the value increased proportion to storage time (p=0.0001). Compared decreasing rate at same sampling time, the more carboplatin was diluted, the more main ingredients decreased (P=0.0001). Conclusions Carboplatin was compatible with normal saline at room temperature for 24 hours. The more carboplatin was diluted and the longer left in room temperature, the more decreasing rate increased. Initial dilution concentration and storage time were effect factors on carboplatin stability after dilution.

Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin. In this study, a liquid chromatography-tandem mass spectrometric method was developed for the quantification of pal-KTTKS, and used for stability and permeability studies. Stability studies were performed using skin extracts and homogenates. Both KTTKS and pal-KTTKS were rapidly degraded, but pal-KTTKS was more stable than KTTKS. When protease inhibitors were added, the stability of both compounds (KTTKS and pal-KTTKS) improved significantly. In the skin permeation study, neither KTTKS nor pal-KTTKS was detected in the receptor solution, which indicates that neither compound could permeate through the full-thickness hairless mouse skin in the experimental conditions of this study. While KTTKS was not detected in any of the skin layers (the stratum corneum, epidermis, and dermis), pal-KTTKS was observed in all skin layers: $4.2{\pm}0.7{\mu}g/cm^2$ in the stratum corneum, $2.8{\pm}0.5{\mu}g/cm^2$ in the epidermis, and $0.3{\pm}0.1{\mu}g/cm^2$ in the dermis. In conclusion, this study indicated that pal-KTTKS had greater stability and permeability than that of un-modified KTTKS, and may be a useful anti-wrinkle and anti-aging cosmeceutical agent.

Purpose: We investigated balance change in patients with low back pain (LBP) by comparing postural sway velocity between young LBP patients and healthy subjects. Methods: The cross-sectional study enrolled 37 young patients with over 3-month duration of LBP and 38 healthy subjects between the ages of 20 and 30 years old. All subjects were targeted by measuring their balance during quiet standing with open eye and closed eye conditions. The postural sway velocity between the LBP patients and healthy subjects was compared. As well, postural sway velocity was determined in the LBP patients with both eyes open and closed. Results: Significant differences were evident in the anteroposterior and mediolateral mean velocity of center-of-pressure between LBP patients and healthy subjects, and in LBP patients in the eye open and eye closed conditions. Conclusion: The balance of young LBP patients was worse than healthy subjects during quiet standing, and was especially lessened in the absence of vision.

This study evaluated the storage stability of a variety of sauce products in the Korean market, determined primary quality indices for three typical products, and proposed functional relationships that are useful for determining shelf life at different temperatures. Most of the products examined were found to combine hurdles of low pH, low water activity, and the use of heat processing as methods for producing the required storage stability while maintaining the sensory quality of the products. For a meat extract solution produced for cold noodles (pH=4.3; $a_w=0.98$), the primary quality change determining shelf life was lipid oxidation, determined here by the TBA value. The primary quality index of a soybean paste seasoning mix (pH=4.0; $a_w=0.78$), which had a microbial load of 2.8 log (CFU/g), was a decrease in its pH. The primary quality index for a sandwich spread (pH=4.0; $a_w=0.88$) was changes in its surface color. The temperature dependence of changes in the primary quality indices can be described by the Arrhenius equation, which can estimate the shelf life at any arbitrary limit as a function of temperature. The activation energies for changes in the primary quality indices of the meat extract solution, the soybean paste seasoning, and the sandwich spread were 20.3, 27.2, and 43.5 kJ/mol, respectively.

The linear instability of reacting shear flow is analyzed with special emphasis on the effects of the heat release and variable transport properties. Both analytic profiles and laminar solutions of the boundary-layer equations are used as base flows. The growth rates of the instabilities are sensitive to the laminar profiles, differing by more than a factor of 2 according to which profile is used. Thus, it is important to base the analysis on accurate laminar profiles. Accounting for variable transport properties also changes the mean profiles considerably, and so including them in the computation of the laminar profiles is equally important. At larger heat release, two modes that are stronger in the outer part of the shear layer have the highest growth rates; they also have shorter wavelengths than the center mode.

This paper presents the dynamic stability of a cantilevered Timoshenko beam with a concentrated mass, partially attached to elastic foundations, and subjected to a follower force. Governing equations are derived from the extended Hamilton's principle, and FEM is applied to solve the discretized equation. The influence of some parameters such as the elastic foundation parameter, the positions of partial elastic foundations, shear deformations, the rotary inertia of the beam, and the mass and the rotary inertia of the concentrated mass on the critical flutter load is investigated. Finally, the optimal attachment ratio of partial elastic foundation that maximizes the critical flutter load is presented.

A slightly curved crack with an eigenstrain is considered. Solutions for a slightly curved crack in a linear isotropic material under asymptotic loading as well as for a slightly curved crack in a linear isotropic material with a concentrated force are obtained from perturbation analyses, which are accurate to the first order of the parameter representing the non-straightness. Stress intensity factors for a slightly curved crack with an eigenstrain are obtained from the perturbation solutions by using a body force analogy. Particular attention is given to the crack path stability under mode I loading. A new parameter of crack path stability is proposed for a crack with an eigenstrain. The path stability of a crack with steady state growth in a transforming material and a ferroelectric material is examined.

Combustion stability characteristics in actual full-scale combustion chamber of a rocket engine are investigated by experimental tests with the model (sub-scale) chamber. The present hot-fire tests adopt the combustion chamber with three configurations of triplet impinging-jet injectors such as F-O-O-F, F-O-F, and O-F-O configurations. Combustion stability bound-aries are obtained and presented by the parameters of combustion-chamber pressure and mixture (oxidizer/fuel) ratio. From the experimental tests, two instability regions are observed and the pressure oscillations have the similar patterns irrespective of injector configuration. But, the O-F-O injector configuration shows broader upper-instability region than the other configurations. To verify the instability mechanism for the lower and upper instability regions, air-purge acoustic test is conducted and the photograph or the flames is taken. As a result, it is found that the pressure oscillations in the two regions can be characterized by the first impinging point of hydraulic jets and pre-blowout combustion, respectively.

복합재로 된 회전날개깃을 상자보로 모델링하고 수동/능동 감쇠를 주기 위해 ACL(Active Constrained Damping Layer)을 상하양면에 부착하고 복합변위이론에 기초한 유한요소방법을 이용하여 구조해석을 수행하였다. 이 이론은 ACL내의 복합재와 점탄성층 그리고 압전층의 전단변형효과를 정확하게 모델링하는데 효과적이다. Hankel 의 특이값을 이용해 축차모델을 유도하였으며 축차모델과 측정된 출력에 기초한 LQG 제어기를 설계하였다. 그러나 LQG 제어기는 공칭 운전속도에서는 좋은 성능을 보여주었으나 운전속도가 변하는 상황에 대해서는 강인안정성을 보여주지 못했다. 이 LQG제어기의 강인안정성을 개선하기 위하여 루프전달회복을 통한 강인한 제어기를 설계하였다. 수치 예를 통해 제시된 제어기가 회전날개깃의 공기역학적인 안정성을 개선하는데 효과적이며 동체모드와 연계된 리드-래그 모드감쇠를 증가시켜 회전날개깃의 진동을 효과적으로 억제하는 것을 보였다.

The rotor blade is modeled using a composite box beam with arbitrary wall. The active constrained damping layers are bonded to the upper and lower surfaces of the box beam to provide active and passive damping. A finite element model, based on a hybrid displacement theory, is used in the structural analysis. The theory is capable of accurately capturing the transverse shear effects in the composite primary structure, the viscoelastic and the piezoelectric layers within the ACLs. A reduced order model is derived based on the Hankel singular value. A linear quadratic Gaussian (LQG) controller is designed based on the reduced order model and the available measurement output. However, the LQG control system fails to stabilize the perturbed system although it shows good control performance at the nominal operating condition. To improve the robust stability of LQG controller, the loop transfer recovery (LTR) method is applied. Numerical results show that the proposed controller significantly improves rotor aeromechanical stability and suppresses rotor response over large variations in rotating speed by increasing lead-lag modal damping in the coupled rotor-body system.

As a series of studies on improving the processing suitability of imported Pacific saury, oxidative stability of seasoned-dried Pacific saury treated with liquid smoke (T2 product) was examined during storage, comparing with control (C, seasoning only) and T1 (treatment of 0.05% BHT instead of liquid smoke). The pH of T2 treated with liquid smoke was relatively lower than those of C and T1 during storage. The contents of volatile basic nitrogen in all products increased continuously during storage. In the changes of TBA and POV of products during storage, the POV of T2 was lower than that of T1, and the TBA values of T1 and T2 were lower than that of C product. The major fatty acids were 22 : 1n-11, 20 : 1n-11, 16 : 0, 14 : 0, 22 : 6n-3, 20 : 5n-3, 18 : 4n-3, 16 : 1n-7, 14 : 1n-7 and 18 : 1n-9 in the both C and T2 products. The contents of polyunsaturated fatty acids in hath C and T2 somewhat decreased with increasing storage period, while those of saturated and monounsaturated fatty acids increased.

In order to enhance suitable processing methods of imported Pacific saury, Cololabis saira, storage stability of seasoned-dried Pacific saury (imported product) treated with liquid smoke (T2 product) was compared with a control (C, seasoning only) and T1 (treatment of 0.05% BHT instead of liquid smoke). The histamine contents of 3 seasoned-dried products were within a stable range (9.08 ~ 12.08 mg/100 g) during storage. The water activities of all products were in the 0.698 ~ 0.755 range. The viable cell count of T2 was lower than those of C and T1 during storage. The change in color values of C, T1 and T2 were not significant with increasing storage period. The results of the sensory evaluation during storage showed that the shelf-life of T2 was extended to 60 days, while those of C and T1 were limited to up to 45 days.

Effects of protein heat treatment and surfactant additionoo the orthokindetic stability of $\beta$-lactoglobulin-stabilized emulsions have been investigated under turbulent flow conditions. In studies on protein-stabilized emulsions, samples which had been subjected to heat treatment(i.e. the protein solution orthe emulsion) have been found to be more prone to orthokinetic coalescene than the untreated ones. The emulsions stabilized with protein heated above the denaturation temperature(i.e. 7$0^{\circ}C$) showed the bigger initial average droplet size, which resulted in an increased orthokinetic coalescenece rate. The storage of the protein-stabilized emulsion at high temperature prior to the shearing experiment also made the emulsion less stable in the shear field. Interestingly. the addition of DATEM has been found to produce a substantial increase in orthokinetic stability of the heat-denatured protein-stabilized emulsion system, although Tween 20 is the opposite case.

Curcumin is a flavonoid found in the rhizome of the turmeric plant (Curcuma longa L.) and has recently attracted interest because it has numerous biological functions and therapeutic properties. In the present study, we attempted to incorporate curcumin into medium-chain triglyceride (MCT) nanoemulsions (0.15 wt% curcumin, 10 wt% MCT oil, and 10 wt% emulsifiers) with various emulsifiers [polyoxyethylene (20) sorbitan monolaurate (Tween-20), sorbitan monooleate (SM), and soy lecithin (SL)]. The physicochemical properties of the nanoemulsions including the Ostwald ripening stability were investigated. The initial droplet size was found to be 89.08 nm for the nanoemulsion with 10 wt% Tween-20 (control), and when Tween-20 was partially replaced with SM and SL, the size decreased: 73.43 nm with 4 wt% SM+6 wt% Tween-20 and 67.68 nm with 4 wt% SL+6 wt% Tween-20 (prepared at 15,000 psi). When the nanoemulsions were stored for 28 days at room temperature, the droplet size increased as the storage time increased. The largest increase was observed for the control nanoemulsion, followed by the 4 wt% SL+6 wt% Tween-20 and 4 wt% SM+6 wt% Tween-20 systems. The Turbiscan dispersion stability results strongly supported the relationship between droplet size and storage time. The time-dependent increase in droplet size was attributed to the Ostwald ripening phenomenon. Thus, the Ostwald ripening stability of curcumin-loaded MCT nanoemulsions with Tween-20 was considerably improved by partially replacing the Tween-20 with SM or SL. In addition, curcumin may have acted as an Ostwald ripening inhibitor.