Earticle

초록

영어

Thymic extract showed antitumor effect to sarcoma mice with higher dose i.p., 4weeks) but not with low dose i.p., 6 weeks). Direct cytotoxicities were exhibited against sarcoma 180, L1210 and MOLT-4 by MTT assay. The spleen weight of mice were increased but the number of circulating lymphocytes were not increased after long-term(2 weeks) administration of thymic extract. Evaluating the mitogenesis by MTT assay. absorbance of human lymphocytes was not increased by thymic extract. Cell cycle statistics of S phase and phase was not increased in the presence of that by PI staining. The formation of rosette was induced, irrespectively of exposure time short-term(l hour) and long-term(2 weeks). The population of mouse blood T-cell to bind Lyt2-antimonoclonal antibody and to were increased after administration of thymic extract. From the above results, it is suggested that thymic extract exerts antitumor activity by stimulating T cells to differeniate in vivo but not in vitro.

저자

• 정용자 [ Chung, Yong Za | 경성대학교 약학대학(Dept. of Biochemistry, College of Pharmacy, Kyung-Sung University.) ]
• 홍기태 [ Hong, Gi Tae | 경성대학교 약학대학(Dept. of Biochemistry, College of Pharmacy, Kyung-Sung University.) ]
• 정현옥 [ Jung, Hyun Ok | 한국암연구소(Korean Cancer Reserch Inslitute) ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615