Earticle

초록

영어

The ability to precisely predict serum digoxin concentration using 7 published methods in a group of 50 patients was undertaken. Two methods of estimating creatinine clearance and two estimates of lean body weight were employed as input variables using the 7 dosing methods. TDX was used to determine the nadir SDCs(serum digoxin concentrations) in 50 in patients meeting predetermined study criteria. All patients, whose ages ranged 19-71 years, had steady-state digoxin levels, were in oral digoxin, and were free from liver dysfunction, thyroid dysfunction and renal failure. The correlation coefficients(r) of predicted versus observed SDCs were determined,. and mean error(ME) was determined for each method to reflect bias, respectively. No substantial differance in predictive reliabliity was evident among the methods studied in total group. Poor correlations existed between predicted and observed SDCs(r<0.4) and these correlations were not significantly affected by age and gender. But relatively higher correlation and lower ME was founded for the CHF group in Jelliffe method(r=0.5, p<0.05).

저자

• 류윤미 [ Ryu, Yunmi | 서울대학교 병원 약제부(Seoul National University Hospital pharmary) ]
• 신완균 [ Shin, Wan-Gyoon | 서울대학교 병원 약제부(Seoul National University Hospital pharmary) ]
• 이명걸 [ Lee, Myung-kul | 서울대학교 약학대학(Collegy of pharmacy. Seoul national university) ]
• 이민화 [ Lee, Min-Hwa | 서울대학교 병원 약제부, 서울대학교 약학대학(Seoul National University Hospital pharmary, Collegy of pharmacy. Seoul national university) ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615