Purpose: This study examined the relationships between job stress, coworker support, rewards and retention intention among hospital nurses. Methods: A descriptive correlational design was used with 154 nurses from one tertiary and two general hospitals in B city, South Korea. Job stress, coworker support, rewards and retention intention were measured using validated instruments. Data were analyzed using descriptive statistics and multiple regression analysis. Results: Job stress was negatively correlated with retention intention, whereas coworker support and rewards were positively correlated. Multiple regression analysis revealed that job stress (β=-.34, p<.001), coworker support (β=.25, p=.001) and rewards (β=.20, p=.010) were significantly correlated with retention intention, explaining 38.0% of the variance (F=11.43, p<.001). Conclusion: Job stress, coworker support and rewards were significantly correlated with retention intention among hospital nurses. These findings suggest that organizational factors should be considered in efforts to improve nurses’ retention intention.