Earticle

초록

영어

This study investigated the effects of Ulleung deep ocean water extract on melanin pigmentation, skin tissue recovery, and inflammatory responses in a UVB-induced skin damage animal model. Brown guinea pigs were divided into normal, control, positive control, and extract-treated groups, and test materials were topically applied for four weeks after UVB irradiation. Melanin pigmentation was evaluated using the melanin index, Fontana-Masson staining, and S-100 expression. Skin tissue, dermal fiber, and inflammatory changes were assessed using H&E, Masson’s trichrome, Gomori’s reticulum fiber, and Toluidine blue staining. The extract-treated group showed lower melanin index, pigmentation, and S-100 expression than the control group. Epidermal and dermal damage was alleviated, collagen and reticular fiber arrangements showed recovery, and mast cell-related inflammatory responses were reduced. These findings suggest that Ulleung deep ocean water extract may reduce UVB-induced pigmentation, promote skin tissue recovery, and alleviate inflammation. Although skin barrier function was not directly measured, the results suggest a favorable environment for barrier recovery. Overall, Ulleung deep ocean water extract may have potential as a functional cosmetic ingredient.

중국어

本研究旨在UVB诱导皮肤损伤的动物模型中评价郁陵深层水提取物对黑色素色素沉 着皮肤组织修复以及炎症反应的作用将棕色豚鼠分为正常组对照组阳性对照组以及 郁陵深层水提取物涂抹组 UVB照射后连续4 周涂抹受试样品 通过黑色素指数 Fontana‑Masson染色S‑100蛋白表达评估黑色素色素沉着采用H&E染色Masson三色染 色Gomori网状纤维染色甲苯胺蓝染色分析皮肤组织真皮纤维结构与炎症反应结果 显示与对照组相比郁陵深层水提取物涂抹组的黑色素指数色素沉着程度S‑100蛋白表 达均有所下降表皮与真皮损伤得到缓解胶原纤维网状纤维排列得到修复肥大细胞介 导的炎症反应也有所降低上述结果提示郁陵深层水提取物能够缓解UVB诱发的皮肤色素 沉着对皮肤组织修复减轻炎症反应具备积极作用但本研究并未直接测定皮肤屏障功 能因此该结果更适合解读为提取物有助于构建利于皮肤修复的皮肤环境而非直接证实 皮肤屏障修复功效本研究结果表明郁陵深层水提取物具备作为功能性化妆品原料的开发 应用潜力

목차

Abstract
I. 서론
II. 이론적 배경
1. 자외선과 피부손상
2. 멜라닌 생성과 미백기능
3. 피부조직 손상과 주름개선 관련 기전
4. 피부장벽 기능과 염증반응
5. 해양심층수와 피부미용 소재로서의 가능성
6. 가설설정
III. 연구방법
1. 실험재료 및 기기
2. 동물실험과정
3. 울릉심층수 추출물 제조 및 UVB 유도 피부손상 모델
4. 시료 도포
5. 분석방법
IV. 연구결과 및 고찰
1. 울릉심층수 추출물의 미백효과
2. 울릉심층수 추출물의 피부조직 및 콜라겐 섬유 회복효과
3. 울릉심층수 추출물의 염증반응 완화 및 피부장벽 회복 가능성
V. 결론
참고문헌
中文摘要

키워드

저자

• 이태종 [ Lee Tae Jong | 계명문화대학교 보건행정학과 겸임교수 ]
• 김정원 [ Kim Jung Won | (주)울릉심층수 부사장 ]
• 박사라 [ Park Sa Ra | 계명문화대학교 보건행정학과 조교수 ]
• 장영혜 [ Jang Young Hye | 경운대학교 지역산업학과 연구교수 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  국제보건미용학회지 [Journal of Health and Beauty]

• 간기

  계간

• pISSN

  2005-369X

• eISSN

  2765-1347

• 수록기간

  2007~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 593 DDC 646