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Session 5 : Medical & Health Studies for Co-Prosperity

Discovery and Efficacy of Filaggrin and TNF-α Modulating V. amygdalina Leaf derived Biomaterials (AMXs) on Inflammatory Skin Diseases

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  • 발행기관
    선문효정학술연구회 바로가기
  • 간행물
    선문효정학술연구회 학술대회 프로시딩 바로가기
  • 통권
    Proceedings of THE 4th INTERNATIONAL CONFERENCE OF HYOJEONG ACADEMY & 2024 INTERNATIONAL JOINT CONFERENCE (2024.08)바로가기
  • 페이지
    pp.106-110
  • 저자
    Nlandu Roger Ngatu, Luzitu Severin Nangana, Christian Wansu-Mapong, Juhachi Saichi, Yukimi Nakamura , Marie Nsimba-Miezi, Nzunzu Jose-Lami
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A489299

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원문정보

초록

영어
Environmental inflammatory skin diseases, such as atopic dermatitis (AD) and contact dermatitis (CD) are 12 common skin disorders in both industrialized and developing countries. They are characterized by a defect of 13 the skin barrier and increased inflammatory response. Worldwide, the prevalence of environmental and 14 occupational dermatitis has increased exponentially during the COVID-19 pandemic due to the elevated 15 utilization of disinfectants and personal protective equipment (PPE). Steroids have long been used as the first 16 line treatment for dermatitis; but considering their side effects and contraindications, there is a need of effective 17 treatments with better safety profile. This mini-review highlights the skin health benefits of African plant V. 18 amygdalina leaf extracts (AMXs). We conducted experimental studies using mouse models of allergic contact 19 dermatitis (ACD), which showed that its aqueous (AMX1) and ethanolic (AMX2) leaf extracts were as effective 20 as topical steroid preparation in preventing ACD and relieving the number of scratching counts, skin erosion 21 and excoriation. Another study (immuno-fluorescence assay) showed that AMX and AMX-contained Vernodalin 22 both have significantly increased the production of filggrin (FLG) in mouse skin and reduced plasma TNF-alpha 23 (vs. steroid). In our clinical investigation among Congolese patients with moderate AD and CD (N=25), AMX1 24 and AMX2 were as effective as steroid preparation; but relatively more effective in relieving pruritus and 25 wounded skin. Findings from this research suggest that AMXs improve skin barrier, with good efficacy and 26 safety profiles, and may serve as effective therapeutic agents for inflammatory skin diseases.

목차

Abstract
1. Introduction
2. Materials and Methods
2.1. Study desing
2.2. Assessment of disease severity and Treatments
2.3. Data Analysis
3. Results
3.1. Epidemiological profile of Atopic dermatitis and Contact dermatitis
3.2. Mechanisms of Action of AMXs
3.3. Experimental Efficacy of Topical application of AMXs in Muse Models of Contact Allergy
3.4. Clinical Efficacy and Safety of Topical application of AMXs in AD and CD Patients
4. Discussion
5. Conclusions
References

키워드

Atopic dermatitis Contact dermatitis Eczema area severity index (EASI) Vernonia amygdalina

저자

  • Nlandu Roger Ngatu [ Congo-Japan NCDs Research Group/ Kagawa Univerdity Faculty of Medicine, Kagawa, Japan ] Corresponding Author
  • Luzitu Severin Nangana [ Congo-Japan NCDs Research Group/ Hopital Kimbanguiste de Kinshasa, Kinshasa, D.R. Congo (DRC) ]
  • Christian Wansu-Mapong [ Congo-Japan NCDs Research Group/ Division of Health Sciences, Institut Superieur Technique Songwa, Kinshasa, DRC ]
  • Juhachi Saichi [ Congo-Japan NCDs Research Group ]
  • Yukimi Nakamura [ Congo-Japan NCDs Research Group/ Hopital Kimbanguiste de Kinshasa, Kinshasa, D.R. Congo (DRC) ]
  • Marie Nsimba-Miezi [ Congo-Japan NCDs Research Group/ Division of Health Sciences, Institut Superieur Technique Songwa, Kinshasa, DRC ]
  • Nzunzu Jose-Lami [ Congo-Japan NCDs Research Group/ Division of Health Sciences, Institut Superieur Technique Songwa, Kinshasa, DRC ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
  • 설립연도
    2023
  • 분야
    복합학>학제간연구
  • 소개
    Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.

간행물

  • 간행물명
    선문효정학술연구회 학술대회 프로시딩
  • 간기
    반년간
  • 수록기간
    2023~2026
  • 십진분류
    KDC 238 DDC 289

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