Earticle

초록

영어

The extreme environment of Antarctica fosters the production of unique secondary metabolites by its native lichens, mosses, and bacteria. These natural products present valuable opportunities for drug discovery due to their distinctive bioactivities and chemical diversity. In this study, the potential of Antarctic-derived metabolites was examined and emphasized the role of advanced analytical and computational techniques in investigating these compounds. Our studies have demonstrated that extracts from Antarctic mosses, lichens, and bacteria exhibit significant bioactivities, including anticancer, antituberculosis, anti-obesity, and anti-diabetic effects. By integrating metabolomics within silico analyses, we were able to swiftly and precisely identify bioactive compounds. The use of molecular networking allowed us to map and categorize related metabolites, while molecular docking and ADME (absorption, distribution, metabolism, and excretion) evaluations provided insights into their pharmacokinetic properties and therapeutic potential. This robust methodological approach has led to the identification of several promising bioactive compounds, highlighting the potential of these Antarctic organisms in drug development. Looking ahead, we advocate for the inclusion of genetic analysis and synthetic biology techniques to further investigate and harness these natural products. Genetic studies can elucidate biosynthetic pathways, and synthetic biology can facilitate the optimization and scalable production of these bioactive compounds. In summary, the combination of metabolomics, in silico analysis, genetic research, and synthetic biology offers a powerful strategy for discovering novel pharmacologically active compounds from Antarctic natural products. This study seeks to spotlight the untapped potential of these resources and promote their integration into the drug discovery pipeline.

목차

Abstract
1. Introduction
2. Materials and Methods
2.1. Sample Collection and Preparation
2.2. Sample processing and extraction
2.3. Metabolic profiling
2.4. Compound Purification and Structural Analysis
2.5. In silico analysis
3. Results
3.1. Bioactive Metabolites from Antarctic Mosses, Lichens, and Bacteria
3.2. Untargeted metabolic profiling on Moss/Lichen metabolites
3.3. Molecular docking and ADME analysis
3.4. Biosynthetic Gene Cluster (BGCs) Analysis
4. Discussion
5. Conclusions
References

키워드

저자

• Ryoichi Yamada [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ]
• Kristina Lama [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ]
• Hirotake Yamaguchi [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ]
• Tae-Jin Oh [ Department of Life Science and Biochemical Engineering, Sun Moon University/ Genome-based BioIT Convergence Institute, Sun Moon University ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  선문효정학술연구회 학술대회 프로시딩

• 간기

  반년간

• 수록기간

  2023~2026

• 십진분류

  KDC 238 DDC 289