Earticle

초록

영어

Airway inflammatory diseases like asthma is a global public health concern due to their chronic inflammatory effects on the respiratory mucosa. Recently, the application of molecular hydrogen (H₂) has been recognized for its antioxidant and anti-inflammatory properties. In this study, we investigated the therapeutic potential of H₂ in airway inflammation using an ovalbumin (OVA)-induced BALB/c mouse model of allergic asthma. Female BALB/c mice were sensitized and challenged with OVA to induce airway inflammation and thirty mice were randomly divided into five groups: NT (non-treatment), HTC (3% H₂ treatment only), NC (negative control, OVA only), PC (positive control, OVA + intranasal 1 mg/ml salbutamol 50μl), and HT (H₂ treatment, OVA + inhaled 3% H₂). Various inflammatory and oxidative stressinduced markers such as WBC and its differential counts, lung histology, reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxidase (GPx), and catalase (CAT), cytokine levels such as interferongamma (IFN-γ), interleukin (IL)-4, tumor necrosis factor-alpha (TNF-α), (IL)-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), (IL)-5, (IL)-13, and total immunoglobulin E (IgE) levels were investigated. Our results demonstrated that inhaled H₂ significantly reduced inflammatory cell infiltration, oxidative stress markers, and pro-inflammatory cytokines expression while upregulating antioxidant enzyme activity. Additionally, H₂ also significantly decreased serum IgE levels, a marker of allergic inflammation. Collectively, our findings suggest that H₂ inhalation could be a promising treatment option for airway inflammation, offering a novel approach with potential clinical applications.

키워드

저자

• Wenjing He [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea/Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea ]
• Md. Habibur Rahman [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea ]
• Johny Bajgai [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea ]
• Sofian Abdul-Nasir [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea/Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea ]
• Chaodeng Mo [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea/Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea ]
• Hui Ma [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea/Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea ]
• Goh Seong Hoon [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea ]
• Kim Bomi [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea ]
• Hyungdon Lee [ Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Chuncheon 24253, Republic of Korea ]
• Cheol-Su Kim [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea ]
• Kyu-Jae Lee [ Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea/Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회 학술대회

• 간기

  부정기

• 수록기간

  2013~2024

• 십진분류

  KDC 539 DDC 628