Earticle

초록

영어

The aim of this study was to investigate the therapeutic potency of Rehmanniae Radix extract (RRE) in in vitro and in vivo psoriasis models. HaCaT keratinocytes were stimulated with M5 (mixture of IL- 17A, IL-22, IL-1α, oncostatin M, and TNF-α) for development of a psoriatic keratinocyte model in vitro. The expression of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathways were detected by western blot. In vivo experiment, the psoriasis-like skin inflammation mice model was established by 5% imiquimod (IMQ). RRE treatment significantly attenuated skin inflammation and improved skin integrity in imiquimod-treated mice by suppressing keratinocyte hyperproliferation, inhibiting the infiltration of immune cells, and downregulating the expression of psoriatic markers. Further, ADE treatment suppressed JAK2/STAT3 signaling in HaCaT cells. Overall, the application of RRE relieves psoriasis-like skin inflammation possibly by regulating the JAK2/STAT3 signaling pathways, making it an effective alternative for psoriasis therapy.

키워드

저자

• Mi Hye Kim [ College of Korean Medicine, Woosuk University ]
• Dae Yong Kim [ College of Korean Medicine, Woosuk University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회 학술대회

• 간기

  부정기

• 수록기간

  2013~2024

• 십진분류

  KDC 539 DDC 628