Earticle

초록

영어

Eucommia ulmoides OLIVER is a medicinal plant that is grown in East Asia including Korean, China and Japan. Radix of E. ulmoidesis reported to lower blood pressure, prevent osteoporosis and regulate the immune system. This study aimed to verify the inhibitory effects of E. ulmoideson lipopolysaccharide (LPS)-induced intestinal epithelial inflammation. C57BL/6J male mice were pre-treated with 20 and 200 mg/kg of E. ulmoidesextract 2 time per day. After 3 days, LPS was intraperitoneally injected and then mice were sacrificed following 16 hours. Disease Activity Index (DAI) score was calculated as total score including body weight decrease, stool consistency and rectal bleeding divided by 3. The expressions of PINK1/Parkin-related molecules were analyzed in the colon tissues with the histopathology. Treatment with the E. ulmoidesextract significantly inhibited the DAI score in LPS-induced intestinal inflammatory murine model. E. ulmoideseffectively prevent LPS-induced weight loss, impairment of intestinal tissues, and histological evidence of inflammation. Additionally, the levels of PINK1, Parkin and LC3 II, known as molecular markers of mitophagy, were notably reduced in E. ulmoides-treated colon tissues. Furthermore, E. ulmoides administration showed the inhibition of NLRP3 inflammasome complex. The present study exhibited that E. ulmoidestreatment could regulate the PINK1/Parkin cascade of mitophagy, after which inhibit the production of NLRP3 inflammasome complex. The findings of this study suggest that E. ulmoides might be an effective therapeutic agent for treating intestinal inflammation.

키워드

저자

• Mi Hye Kim [ College of Korean Medicine, Woosuk University ]
• Dae Yong Kim [ College of Korean Medicine, Woosuk University ]

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간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회 학술대회

• 간기

  부정기

• 수록기간

  2013~2024

• 십진분류

  KDC 539 DDC 628