Earticle

현재 위치 Home

Posters 10

Inhalation of peppermint oil by nebulizing attenuated asthma via inflammatory IL-6/JAK2/STAT3 signaling pathway

첫 페이지 보기
  • 발행기관
    한국물학회 바로가기
  • 간행물
    한국물학회 학술대회 바로가기
  • 통권
    2024 International Conference of KWS with 4th Annual Meeting of ISHMB (2024.11)바로가기
  • 페이지
    pp.35-35
  • 저자
    Mi Hye Kim, Dae Yong Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A475523

원문정보

초록

영어
Asthma is one of the crucial inflammatory diseases with wheezing, breathlessness, chest tightness and coughing. It is accompanied with the airway hyperresponsiveness, pulmonary inflammation and airway remodeling. Recently, inhalation of essential oils from aromatic plants has been reported to have therapeutic effects for respiratory disease. In this study, we verified the inhibitory effects of peppermint oil inhalation using a nebulizer in mice. Network pharmacology analysis was conducted to predict the functional mechanism of peppermint oil prior to animal experiment. The target genes of menthol and menthone, main compounds of peppermint oil, consisted of the whole network and then analysed in both of KEGG pathway and GO Biological process databases. Based on the results from Network pharmacology, cytokine expression and the IL-6/JAK2/STAT3 signaling pathway were confirmed in lung epithelial cells and asthmatic mice. Through a network pharmacological analysis, cytokine-cytokine receptor interaction and JAK/STAT was expected to be potential mechanisms of peppermint oil. Fine particulate matter (PM)- exposed lung epithelial cells showed the decreases of pro-inflammatory and T helper 2-specific cytokines by peppermint oil treatment. Inhalation of peppermint oil by nebulization also reduced the IL-6 levels and JAK2/STAT3 phosphorylation in PM-exposed lung tissues. Moreover, respiratory epithelium hyperplasia, collagen deposition and goblet cell activation were ameliorated in peppermint oil-treated asthmatic mice. Taken together, inhalation of peppermint oil significantly down-regulated the IL-6/JAK2/STAT3 signaling pathway in inflamed lung tissues. Peppermint oil may have an inhibitory effect on inflammatory asthma under the condition of PM-exposure.

키워드

Asthma JAK Peppermint oil STAT

저자

  • Mi Hye Kim [ College of Korean Medicine, Woosuk University ]
  • Dae Yong Kim [ College of Korean Medicine, Woosuk University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국물학회 [The Korean Water Society]
  • 설립연도
    2010
  • 분야
    자연과학>생물학
  • 소개
    기능수관련연구 경영과 정보를 공유, 일본 중국기능수재단 협회전문가 초빙하여 학회와의 정보교류 기능수관련 학회 및 학술지를 발행하여 물관련연구정보교류에 목적을 두고 있음.

간행물

  • 간행물명
    한국물학회 학술대회
  • 간기
    부정기
  • 수록기간
    2013~2024
  • 십진분류
    KDC 539 DDC 628

이 권호 내 다른 논문 / 한국물학회 학술대회 2024 International Conference of KWS with 4th Annual Meeting of ISHMB

    피인용수 : 0건 (자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      출처 : 네이버학술정보

        0개의 논문이 장바구니에 담겼습니다.

        페이지 저장
        소속기관 조회
        이용자님의 소속기관(단체)이 서비스에 가입되어 있는지 확인해 보십시오.
        기관회원에 소속되어 있는 이용자는 원문을 무료로 이용할 수 있습니다.