Earticle

초록

영어

Hydrogen molecules have a wide-spectrum anti-oxidation and anti-inflammation effect, and exhibit a clear biological effects and high biosafety in treatment of many inflammation-related diseases. Hydrogen therapy becomes an emerging and promising therapeutic strategy. However, hydrogen medicine currently faces three major problems, including (1) what is the fundamental principle of hydrogen therapy; (2) how to detect hydrogen molecules in vivo; (3) how to deliver hydrogen molecules to the focus. In an attempt to address these issues, our research group does researches about principle exploration, tool development and materials application, harvesting a series of innovative achievements, mainly including: (1) we have discovered the biological target of hydrogen molecules, and revealed the fundamental principles of H2 anti-inflammation, anti-cancer and anti-senescence; (2) we have developed the first bio-probe of H2, and testified high biobarriers- crossing capability of H2; (3) we have developed a series of novel H2-delivering biomaterials to enhance H2 delivery efficacy and applied these materials for treatment of major diseases.[1-10] This report will present the related research advances achieved by us in the recent years.

중국어

氢分子具有广谱抗炎抗氧化效应，在炎症相关的众多重大疾病中展现出明确的生物学效应和较高的 生物安全性。氢气治疗成为一种新兴的、且非常有应用前景的治疗策略。但目前氢医学面临着三大 难题：(1) 氢气治疗的原理是什么；(2) 如何在体内检测氢气；(3) 如何向体内递送氢气。针对这三 大难题，本课题组在原理探究、工具开发、材料应用三个方面开展研究，取得了系列创新性研究成 果，主要包括：(1) 发现了氢分子生物学靶点，揭示了氢分子抗炎、抗癌、抗衰的基本原理；(2) 开 发了首例氢分子生物探针，证实了其高的跨生物屏障能力；(3) 开发了系列新型氢递送医用材料， 提高了氢气递送效率，并应用于重大疾病治疗。本报告将汇报本课题组近年来在这三个方面的研究 进展。[1-10]

키워드

저자

• Qianjun He [ Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai 200240, China ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회 학술대회

• 간기

  부정기

• 수록기간

  2013~2024

• 십진분류

  KDC 539 DDC 628