Earticle

초록

영어

Purpose: To explore sensitive skin facial physiological parameters and lipid differences caused by skin aging. Methods: Female volunteers with sensitive skin were enrolled into the S1 group (22-28 years old) and the S2 group (29-35 years old). Skin surface lipid samples and physiological parameters were collected by non-invasive methods. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) techniques and partial least squares-discriminant analysis (PLS) were used to identify differential lipids. Results: Significant differences in skin elasticity, b* value and ITA was observed between S1 and S2 groups (p<0.05). In lipid profiling analysis, the two groups displayed a good degree of separation. There were five VIP lipids with significant differences between the two groups, including PA(20:0/22:2(13Z,16Z)) and Cer(d18:0/24:0). Lipids showed a significantly correlation with skin elasticity and ITA value (p<0.05). According to ROC analysis, the AUC values of PG(20:0/22:1 (11Z)) and Cer(d18:0/24:0) are greater than 0.7. The results showed that the prediction performance of these two lipids was better and more representative than other lipids. Conclusion: Compared with S1 group, the facial barrier function of the volunteers in S2 group did not change significantly, indicating that the effect of sensitive skin on the skin was stronger than the change of age on the skin barrier function in a certain period of time. Significant changes in elasticity, radiance and differential lipids involved in inflammation indicate that the volunteers in S2 group had exhibited a trend of early aging along with inflammatory aging.

한국어

목적: 피부 노화로 인해 민감한 피부의 얼굴 생리학적 매개 변수와 지질의 차이를 확인하고자 한다. 방법: 민감성 피부를 가진 여 성 지원자를 모집하여 S1 그룹(22-28세)과 S2 그룹(29-35세)으로 구분하였다. 피부 표면 지질 샘플과 생리학적 매개변수는 비침 습적 방법으로 수집하였고, 초고성능 액체 크로마토그래피 4중극자 비행 시간 질량 분석법(UPLC-Q-TOF-MS)과 부분 최소 제곱 판별 분석(PLS)을 사용하여 차등 지질을 식별하였다. 결과: S1군과 S2군 사이에 피부탄력, b* 값, ITA에서 유의한 차이가 관찰되었 다(p<0.05). 지질 질량분석에서 두 그룹은 양호한 수준의 분리를 나타냈다. PA(20:0/22:2(13Z,16Z)) 및 Cer(d18:0/24:0)를 포함하 여 두 그룹 간에 유의미한 차이가 있는 5개의 VIP 지질을 확인하였다. 지질은 피부 탄력도와 ITA 수치와 유의한 상관관계를 보였다 (p<0.05). ROC 분석에 따르면 PG(20:0/22:1(11Z))와 Cer(d18:0/24:0)의 AUC 값이 0.7보다 크다. 이 두 지질의 예측 성능이 다른 지질보다 우수하고 대표성이 있음을 보여주었다. 결론: S1군과 비교하여 S2군 지원자들의 얼굴 장벽 기능은 큰 변화가 없었으며, 이는 특정 기간 동안 민감성 피부가 피부에 미치는 영향이 연령 변화보다 피부 장벽 기능에 더 강한 것으로 나타났다. 염증과 관련 된 탄력성, 윤기 및 차등 지질의 유의한 변화는 S2 그룹의 지원자들이 염증성 노화와 함께 조기 노화 경향을 나냈타다.

중국어

目的: 探究敏感性皮肤面部生理参数及脂质因皮肤老化而产生的差异。方法: 招募敏感性皮肤的女性志愿者，将 其分为S1组(22-28 岁)和S2组(29-35 岁)。通过非侵入性方法采集皮肤表面脂质样本和生理参数。采用超高效液 相色谱四极杆飞行时间质谱(UPLC-Q-TOF-MS)技术和偏最小二乘判别分析(PLS)来鉴定差异脂质。结果: S1组和 S2组在皮肤弹性、b*值和ITA值方面存在显著差异(p <0.05)。在脂质谱分析中，两组显示出良好的分离度。两组 间存在五个具有显著差异的VIP脂质，包括PA(20:0/22:2(13Z,16Z))和Cer(d18:0/24:0)。脂质与皮肤弹性和ITA 值显著相关(p <0.05)。根据ROC分析，PG(20:0/22:1(11Z))和Cer(d18:0/24:0)的AUC值大于0.7。结果表明，这 两种脂质的预测性能优于其他脂质，且更具代表性。结论: 与S1组相比，S2组志愿者的面部屏障功能未发生显 著变化，这表明在一定时期内，敏感性皮肤对皮肤的影响比年龄变化对皮肤屏障功能的影响更强。弹性、光泽 度以及与炎症相关的差异脂质的显著变化表明，S2组志愿者出现了早期衰老以及炎症性衰老的趋势。

목차

Abstract
Introduction
Materials and Methods
1. Study subjects and inclusion criteria
2. Skin physiological parameters and lipid collection
3. Lipid extraction and sample preparation
4. UPLC analysis conditions
5. Data analysis
Results
1. Effects of aging on the physiological parameters of female sensitive skin
2. Facial lipid clustering in S1 and S2 groups
3. Relative abundance of facial lipids in S1 and S2 groups
4. Identification of differential lipid species between S1 and S2 groups
5. Correlation between five VIP lipids and physiological parameters
Discussion
Conclusion
References
국문초록
中文摘要

키워드

지질체학 황제내경 민감피부 피부노화 탄력 Lipidomics The Yellow Emperor Internal Classic Sensitive skin Skin aging Elasticity 脂质组学，黄帝内经，敏感性皮肤，皮肤衰老，弹性

저자

• Rong Tang [ 당영 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ]
• Huiliang Li [ 이혜양 | Hangzhou Huaningxiang Biotechnology Co., Ltd., Hangzhou, Zhejiang Province, China ]
• Yangyang Fang [ 방양양 | Hangzhou Huaningxiang Biotechnology Co., Ltd., Hangzhou, Zhejiang Province, China ]
• Xiaoqian Yu [ 우소건 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ]
• Pengyu Xiao [ 소붕우 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ]
• Congfen He [ 하총분 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ]
• Huaming He [ 하화명 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ]
• Yan Jia [ 가염 | Key Laboratory Cosmetics, China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China ] Corresponding Author

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