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Reversible aggregation and dissociation of chitosan-coated nanoparticles for lung-targeted drug delivery

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2019 International Symposium of Institute of Forest Science (2019.09)바로가기
  • 페이지
    pp.133-133
  • 저자
    Song-Yi Lee, Ja-Seong Koo, Min-Gyu Yang, Hyun-Jong Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450372

원문정보

초록

영어
Reversible aggregation and dissociation of chitosan (CS)-coated nanoparticles (NPs) including phloretin (Phl) after intravenous injection were elucidated to inhibit lung metastasis of melanoma in this study. Phl was encapsulated in poly(D,L-lactide-coglycolide) (PLGA) NPs as an anticancer agent, and CS was adsorbed onto the exterior surfaces of the Phl-loaded PLGA NPs (PLGA/Phl NPs). PLGA/Phl NPs (mean diameter: 194 nm; polydispersity index: 0.03; zeta potential: –37.9 mV; drug encapsulation efficiency: 79%), and CS-coated PLGA/Phl NPs (CS–PLGA/Phl NPs, mean diameter: 342 nm; polydispersity index: 0.19; zeta potential: 23.3 mV; drug encapsulation efficiency: 93%) were successfully fabricated. The deposition of the CS layers in the external surfaces of the CS–PLGA/Phl NPs was evaluated by X-ray photoelectron spectroscopy. PLGA/Phl NPs maintained their initial particle size in serum albumin, while CS–PLGA/Phl NPs exhibited the formation of micro-sized aggregates and easily disassembled into each NP by extrinsic energy. Sustained Phl release pattern from CS–PLGA/Phl NPs and equivalent antiproliferation potential of the Phl-loaded NPs to that of Phl in melanoma (B16F10) cells were confirmed. After multiple injection of designed NPs in lung metastasis mouse models of melanoma, CS– PLGA/Phl NPs group presented significantly lower lung weight and fewer metastasis foci than PLGA/Phl NPs group (p < 0.05). All these findings suggest that the reversible aggregation and dissociation mechanism of NPs can be easily applied to the therapy of lung metastasis of melanoma.

키워드

Anticancer activity Lung metastasis Melanoma Nanoparticle Transient aggregation

저자

  • Song-Yi Lee [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Ja-Seong Koo [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Min-Gyu Yang [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Hyun-Jong Cho [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

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