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Neuroprotective and cognitive enhancing effect of Annona muricata in mice

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2019 International Symposium of Institute of Forest Science (2019.09)바로가기
  • 페이지
    pp.80-80
  • 저자
    Ye-Lim Son, Hyeon-Woo Lee, Chong-Je Ma
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450331

원문정보

초록

영어
The number of a Alzheimer disease's(AD) is increasing as the aging society progresses. AD accompanies memory and behavioral disorders. Since the mechanisms that cause AD are not yet known, studies on the therapeutic agents of this disease have been actively conducted. We examined whether Annona muricata, a natural product, was effective in treating AD. A. muricata is mainly distributed in the tropics of America. This plant traditionally called 'natural remedy' or 'God's gift' and has been used as a treatment for American native. A. muricata contains compounds such as tannin, saponin, flavonoid and antraquinone. We conducted the Morris water meze test and Passive avoidance test with MeOH extracts of A. muricata. Morris water maze test is performed to verify spatial learning abilities. Passive avoidance test is an experiment to check the memory of pain or aversive stimuli. In this study, we confirmed the effects of A. muricata in amnesia mice. We used scopolamine to induce memory and behavioral disturbances. A. muricata shortened the time it took for mice to arrive at buoys in Morris water maze test. In passive avoidance test, A. muricata reduce the latency time. And we have conducted an MTT assay to determine if A. muricata ha cytoprotective effects, and that the high concentrations of A. muricata are effective for cell protection. These results confirm that A. muricata has the effect of ameliorating the symptoms of amnesia mice. It also suggests that this plant has potential for treatment or prevention of AD.

키워드

Annona muricata Alzheimer's disease In vivo test Cell protective effect

저자

  • Ye-Lim Son [ College of Biomedical science, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Hyeon-Woo Lee [ College of Biomedical science, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Chong-Je Ma [ College of Biomedical science, Kangwon National University, Chuncheon 24341, Republic of Korea; Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon 24341, Republc of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

이 권호 내 다른 논문 / 강원대학교 산림과학연구소 학술대회 2019 International Symposium of Institute of Forest Science

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