2019 International Symposium of Institute of Forest Science (2019.09)바로가기
페이지
pp.78-78
저자
Song-Yi Lee, Hyun-Jong Cho
언어
영어(ENG)
URL
https://www.earticle.net/Article/A450329
원문정보
초록
영어
Several cellulose derivatives have been attracted as pharmaceutical excipients for the design of nanostructures aiming at tumor-targeted drug delivery. Cellulose derivatives can form nano-sized carriers by several preparation methods due to their unique physicochemical properties. Nano-sized vehicles can be easily transported and accumulated in tumor tissue after intravenous administration via an enhanced permeability and retention (EPR) effect, known as a passive tumor targeting methodology. To elevate the tumor targeting efficiency, ligand-receptor interactions can be introduced as an active tumor targeting strategy. Cellulose-based nanovehicles can be modified with tumor targeting moieties by physical and chemical modification. Combination of passive and active tumor targeting strategies can provide selective drug delivery to tumor tissue without severe systemic toxicities. Of note, considering biodegradability in the body, natural polysaccharides (i.e., hyaluronic acid and chitosan), which has similar chemical backbones, have been widely used for the fabrication of nanosystems for cancer therapy. Biocompatibility and biodegradability of those materials can accelerate the clinical application of developed nanostructures.
키워드
Cancer therapyCelluloseDrug deliveryNanosystemTumor targeting
저자
Song-Yi Lee [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
Hyun-Jong Cho [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
Corresponding Author