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The application of cellulose derivatives to the development of nanosystems for tumor-targeted drug delivery

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2019 International Symposium of Institute of Forest Science (2019.09)바로가기
  • 페이지
    pp.78-78
  • 저자
    Song-Yi Lee, Hyun-Jong Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450329

원문정보

초록

영어
Several cellulose derivatives have been attracted as pharmaceutical excipients for the design of nanostructures aiming at tumor-targeted drug delivery. Cellulose derivatives can form nano-sized carriers by several preparation methods due to their unique physicochemical properties. Nano-sized vehicles can be easily transported and accumulated in tumor tissue after intravenous administration via an enhanced permeability and retention (EPR) effect, known as a passive tumor targeting methodology. To elevate the tumor targeting efficiency, ligand-receptor interactions can be introduced as an active tumor targeting strategy. Cellulose-based nanovehicles can be modified with tumor targeting moieties by physical and chemical modification. Combination of passive and active tumor targeting strategies can provide selective drug delivery to tumor tissue without severe systemic toxicities. Of note, considering biodegradability in the body, natural polysaccharides (i.e., hyaluronic acid and chitosan), which has similar chemical backbones, have been widely used for the fabrication of nanosystems for cancer therapy. Biocompatibility and biodegradability of those materials can accelerate the clinical application of developed nanostructures.

키워드

Cancer therapy Cellulose Drug delivery Nanosystem Tumor targeting

저자

  • Song-Yi Lee [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Hyun-Jong Cho [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

이 권호 내 다른 논문 / 강원대학교 산림과학연구소 학술대회 2019 International Symposium of Institute of Forest Science

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