Earticle

초록

영어

Gene delivery systems are essentially required for safety delivery of nucleic acids into the cells. They protect nucleic acids against immune response, serum, and elimination mechanism and improve efficacy of nucleic acids. Nonviral systems among them were developed based on electrostatic interaction, encapsulation, and/or absorption. Cellulose is the most common polysaccharide in the world, and it has excellent biological, physical and chemical properties. Cellulose nanocrystals(CNCs) are widely used in a variety of industries and research because of their excellent chemical and physical properties. In biotechnology and biotechnology, many studies are carried out using CNCs, such as biomaterials, tissue engineering and drug delivery. In this study, we determined that CNC-Zinc/DNA combination systems (CZD cluster) could deliver nucleic acids into the cells. CNC-DNA complex was also mixed with cell penetrating peptide(CPP) to enhance transfection efficacy. All systems retarded the migration of the nucleic acid and improved efficiency of the DNA transfection into the cell. CNC could be used to deliver DNA or siRNA in the cell without specific modication of the nucleic acids.

키워드

저자

• Han-Jin Yu [ Department of Biotechnology and Bioengineering, College of Ace, Culture and Engineering, Kangwon National University ]
• Ji-Hyeon Lee [ Department of Biotechnology and Bioengineering, College of Ace, Culture and Engineering, Kangwon National University ]
• Kwang-Suk Lim [ Department of Biotechnology and Bioengineering, College of Ace, Culture and Engineering, Kangwon National University ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  강원대학교 산림과학연구소 학술대회

• 간기

  부정기

• 수록기간

  2017~2024

• 십진분류

  KDC 526 DDC 634