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Magnesium ascorbylphosphate incorporated hyaluronic acid/collagen microneedle reinforced by cellulose nanofiber as transdermal delivery system

첫 페이지 보기
  • 발행기관
    강원대학교 산림과학연구소 바로가기
  • 간행물
    강원대학교 산림과학연구소 학술대회 바로가기
  • 통권
    2019 International Symposium of Institute of Forest Science (2019.09)바로가기
  • 페이지
    pp.72-72
  • 저자
    Long Wenting, Jin-Ah Kim, Madhusudhan Alle, Seung-Hwan Lee, Jin-Chul Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A450323

원문정보

초록

영어
Magnesium ascorbyl phosphate (MAP) was included in microneedle(MN) matrix composed of Cellulose nanofiber (CNF), collagen, trehalose, and hyaluronic acid in order to increase the efficiency of transdermal delivery rate. Dissolving various contants (7.5%, 14%, 24.5%) of MAP in microneedle were replicated by casting the mixtures solution on the surface of the silicone molds, centrifuging and drying in room temperature. In the compressive strength test, we confirmed that the 7.5% of MAP was included in MN the mechanical strength of MN was increased but when 14% and 24.5% of MAP was included in MN the mechanical strength of MN was slightly decreased. Even when the high content of MAP in the MN matrix is 14% and 24.5% the mechanical strength was sufficient for skin perforation. The cumulative amount of MAP permeated though skin had positive correlation to the MAP content in the microneedle matrix. This probably the bottom of a MN matrix seems to act as a carrier for the skin permeation of MAP.

키워드

Magnesium ascorbyl phosphate Hyaluronic acid Microneedle Cellulose nanofiber

저자

  • Long Wenting [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Jin-Ah Kim [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Madhusudhan Alle [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Seung-Hwan Lee [ Division of Forest Materials Science & Engineering, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Jin-Chul Kim [ Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    강원대학교 산림과학연구소 [Institute of Forest Science Kangwon National University]
  • 설립연도
    1975
  • 분야
    농수해양>임학
  • 소개
    강원대학교부설산림과학연구소(이하 “연구소”라 한다)는 산림에 관한 제반 학술적 연구를 통하여 산림자원의 효용을 밝히고 임업 및 임산업의 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    강원대학교 산림과학연구소 학술대회
  • 간기
    부정기
  • 수록기간
    2017~2024
  • 십진분류
    KDC 526 DDC 634

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