Earticle

현재 위치 Home

Research Article

Antioxidant and inflammation inhibitory effects from fruiting body extracts of Ganoderma applanatum

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 KCI 등재 바로가기
  • 통권
    제19권 제4호 (2021.12)바로가기
  • 페이지
    pp.261-271
  • 저자
    Kyung Hoan Im, Jaehyuk Choi, Seung A Baek, Tae Soo Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A406093

※ 기관로그인 시 무료 이용이 가능합니다.

4,200원

원문정보

초록

영어
In this study, the antioxidant and anti-inflammatory effects of methanol extract (ME) and hot water extracts (HE) from the fruiting bodies of Ganoderma applanatum were investigated. The 1,1-diphenyl-2-picryl-hydrazy (DPPH) radical scavenging activity of 2.0 mg/mL ME (94.83%) was comparable to that of butylated hydroxytoluene (96.97%), the reference standard. The hydroxyl radical scavenging activities of ME and HE were similar to that of BHT at 2.0 mg/mL, whereas lipid peroxidation activity of the ME and HE were significantly lower than that of BHT. High-performance liquid chromatography analysis showed that the G. applanatum fruiting bodies contained nine phenolic compounds, which might contribute to antioxidant and anti-inflammatory activities. The survival rate of RAW 264.7 macrophages treated with 2.0 mg/mL ME and HE were 65.23 to 68.12% at 2.0 mg/mL, thereby indicating that the extracts were slightly cytotoxic at the concentration tested. The extracts also inhibited the nitric oxide (NO)-mediated expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide-induced RAW 264.7 macrophages and carrageenan-induced paw edema in rats. The study results demonstrated that the fruiting bodies of G. applanatum possessed good antioxidant and anti-inflammatory activities, which might be used to develop novel anti-inflammatory agents.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Chemicals and reagents
Mushroom extract
Antioxidant assay
Cytotoxicity assay
Anti-inflammatory activity
RESULTS AND DISCUSSION
Antioxidant activity assay
Inflammation inhibitory assay
Inhibitory effect of carrageenan-induced paw edema in rats
ACKNOWLEDGMENTS
REFERENCES

키워드

Antioxidant Anti-inflammatory Edema Ganoderma applanatum Phenolic compound

저자

  • Kyung Hoan Im [ Division of Life Sciences, Incheon National University ]
  • Jaehyuk Choi [ Division of Life Sciences, Incheon National University ]
  • Seung A Baek [ Honam National Institute of Biological Resources ]
  • Tae Soo Lee [ Division of Life Sciences, Incheon National University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

이 권호 내 다른 논문 / 한국버섯학회지 제19권 제4호

    피인용수 : 0(자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      페이지 저장