Earticle

초록

영어

Skin is a complex barrier organ that can fight against various endogenous and exogenous factors. The damaged skin barrier can lead to different skin problems that can exhibit the skin condition such as a decrease of elasticity and sebum level, an increase of water loss, strengthening of keratinocyte cohesion and wrinkle formation, which will eventually lead to different skin diseases. With the current use of chlorine-rich water as disinfectant and its potential in medical field, it is important to check its safety use. The objective of the study was to evaluate skin safety of electrolyzed neutral oxidizing water (ENOW) (pH: 7.11, oxidation reduction potential: 450 mV, available chlorine concentration: 5.0 ppm) after the long-term use (90-day skin application) on the skin of C57BL/6 mice compared to normal control group (NC) treated with tap water (TW) (pH: 7.8, oxidation reduction potential: 500mV, available chlorine concentration: 0.7 ppm). We were measured skin state such as the moisture, elasticity, sebum, pore size, and wrinkle. Oxidative stress markers such as reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxides (GPx) and catalase (CAT) were measuredin using serum and skin lysate samples. Inflammation cytokines such as IL-1α, IL-1β, IL-13, GM-CSF and TNF-α, and the Th1/Th2 cytokines such as IL-2, IL-4, IL-5, IL-6, IL-10 and IL-12 were also analyzed. In consequently, The skin state of ENOW group showed higher level of elasticity and moisture compared to NC group. ROS and NO levels in skin did not show adverse effect in ENOW group. GPx were also controlled in all groups, however, a significant decrease in CAT level was observed in both NC and ENOW groups. Moreover, serum inflammatory cytokine of ENOW group did not show significant difference as compared to NC and TW groups, however, GM-CSF showed a significantly lower level in the ENOW group than NC group. Cytokines related to allergic response showed no difference in the skin. Taken together, long term treatment of ENOW might be safe on skin in vivo . However, more clinical studies are needed to verify the skin safety of ENOW.

키워드

저자

• Md. Habibur Rahman [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Global Medical Science, Graduate School of Yonsei University, Wonju, Gangwon, 26426, Republic of Republic of Korea ]
• Ailyn Fadriquela [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Johny Bajgai [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Seong-Hoon Goh [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Cheol-Su Kim [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Kyu-Jae Lee [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회지 [Korean Journal of Waters]

• 간기

  부정기

• pISSN

  2233-4653

• 수록기간

  2010~2021

• 십진분류

  KDC 539 DDC 628