Earticle

초록

영어

Various neurodegenerative diseases including dementia and cognitive dysfunction pathogenesis are caused due to oxidative stress. Several studies have proved that molecular hydrogen (H2) acts as a therapeutic and preventive anti-oxidant, however, H2 effect on dementia is poorly documented. In the present study, we investigated the effects of H2 inhalation on trimethyltin (TMT)-induced memory dysfunction in the C57BL/6 mice. For this, mice were intraperitoneally injected a single dosage of TMT 2.6 mg/kg body weight. The subjects were randomly divided into the following groups: normal control without TMT induction, TMT only as a negative control (TMT injection + saline administration), positive control group [TMT injection + lithium chloride (50 mg/kg body weight) injection], H2-2wk group [TMT injection + H2 gas inhalation (once a day for 30 min for 2 weeks) and H2-4wk group [TMT injection + H2 gas inhalation (once a day for 30 min for 4 weeks). As a result, TMT-exposed mice showed symptoms such as tremor, seizure and aggressive behavior. Meanwhile, H2-treated groups after TMT treatment showed significantly increased spatial cognition abilities in the Y-maze test. Likewise, the level of the oxidative stress markers such as ROS, NO and MDA were found to be decreased in H2-2wk and H2-4wk groups as compared to the TMT only group in both serum and brain lysate, coherently, antioxidant enzymatic activities were increased in H2-2wk and H2-4wk groups compared to TMT only group. Moreover, H2 showed prevention effect of neuronal apoptosis through the suppression of apoptotic signaling molecules such as BAX, and cleaved caspase-7. Overall, H2 inhalation exhibited memory enhancing activity and decreased the oxidative stress markers and suppressed apoptotic signaling molecules on TMT-inducd mice. Therefore, H2 might be one of candidates for repairing dementia and neuro-degenerative diseases which shows symptoms such as dysfunction of learning, memory and cognition. However further studies are needed to clarify this notion.

키워드

저자

• Johny Bajgai [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Md. Habibur Rahman [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Global Medical Science, Graduate School of Yonsei University ]
• Ailyn Fadriquela [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Subham Sharma [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Global Medical Science, Graduate School of Yonsei University ]
• Dong-Heui Kim [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Seong-Hoon Goh [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• In-Soo You [ GOOTZ Co.Ltd, R&D Center, GOOTZ, 79-6, Yuljeong-ro 247beon-gil, Yangju-si, Gyeonggi-do, Republic of Korea ]
• Yun-Su Na [ GOOTZ Co.Ltd, R&D Center, GOOTZ, 79-6, Yuljeong-ro 247beon-gil, Yangju-si, Gyeonggi-do, Republic of Korea ]
• Nam-Kyu Kong [ GOOTZ Co.Ltd, R&D Center, GOOTZ, 79-6, Yuljeong-ro 247beon-gil, Yangju-si, Gyeonggi-do, Republic of Korea ]
• Soo-Ki Kim [ Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 26426, Republic of Korea ]
• Cheol-Su Kim [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ]
• Kyu-Jae Lee [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회지 [Korean Journal of Waters]

• 간기

  부정기

• pISSN

  2233-4653

• 수록기간

  2010~2021

• 십진분류

  KDC 539 DDC 628