Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamus-pituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.
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Abstract INTRODUCTION CYTOKINES NEUROINFLAMMATION EFFECTS OF NEUROINFLAMMATION ON NEUROTRANSMITTERS EFFECTS OF NEUROINFLAMMATION ON NEUROCIRCUITRY PATHOGENESIS OF NEUROINFLAMMATION IN PSYCHIATRIC DISORDERS POTENTIAL TREATMENT ASSOCIATED WITH THE REGULATION OF NEUROINFLAMMATION CONCLUSIONS CONFLICT OF INTEREST ACKNOWLEDGMENTS REFERENCES