Earticle

초록

한국어

The mechanism of epileptic seizure has not been identified clearly. Ex-ercise can play a role of antioxidants against oxidative stress. In the present study, the neuroprotective effects of preconditioning exercise on epileptic seizure were investigated with focusing on antioxidants activity in the hippocampus. Rats were allocated to the following groups: saline control group, kainic acid control group, and previous exercise and kainic acid group. Rats in the previous exercise and kainic acid group were subjected to treadmill exercise 5 days a week for 4 weeks. After 48 hr of exercise period, rats in the kainic acid control group and previ-ous exercise and kainic acid group were injected with kainic acid. The number of neuronal nitric oxide synthase-positive cells and the level of nitrite in hippocampus were increased and the expressions of superox-ide dismutase-1, superoxide dismutase-2, and catalase in hippocampus were reduced in kainic acid control group compared with saline control group. By contrast, in the previous exercise and kainic acid group, the number of neuronal nitric oxide synthase-positive cells and the level of nitrite were decreased and the expressions of superoxide dismutase-1, superoxide dismutase-2, and catalase were increased compared with the kainic acid control group. Preconditioning exercise may have neu-roprotective effects against oxidative stress via increased antioxidant activity in the hippocampus of epileptic seizure.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Exercise protocol
Epileptic seizure
Tissue preparation
Immunohistochemistry
Western blotting
Nitrite assay
Statistical analysis
RESULTS
Effects of previous exercise on the number ofnNOS-positive cells in dentate gyrus
Effects of previous exercise on nitrite level in hippocampus
Effects of previous exercise on SOD-1, SOD-2, and CAT expressions in hippocampus
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sam-Jun Lee [ Department of Physical Education, College of Health, Social Welfare, and Education, Tongmyong University, Busan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613