Earticle

초록

영어

Sildenafil citrate is a potent and selective inhibitor of phosphodiester-ase type-5 used to treat erectile dysfunction. We investigated the ef-fects of sildenafil citrate treatment on peripheral fatigue and exercise performance after exhaustive swimming exercise in rats. The rats in the sildenafil citrate-treated groups received sildenafil citrate orally once a day for 14 consecutive days at respective dosage. On the 14 days after starting experiment, each animal was submitted to swimming test with intensity equivalent to overload. The exhaustion was defined as a state in which coordinated movements did not return to the water surface for breathing within 10 sec. Western blot for monocarboxylate transporter (MCT)1, MCT4, and neuronal nitric oxide synthase (nNOS) were per-formed. Exhaustive swimming exercise decreased time of exhaustion and increased lactate concentration, however, sildenafil citrate en-hanced time of exhaustion and decreased lactate concentration. Ex-haustive swimming exercise increased MCT1 and MCT4 expressions in the gastrocnemius muscles and sildenafil citrate further enhanced MCT1 and MCT4 expressions in the exhaustive swimming exercise rats. Exhaustive swimming exercise decreased nNOS expression in the gastrocnemius muscles and sildenafil citrate enhanced nNOS expres-sion in the exhaustive swimming exercise rats. The most potent effect appeared in the 20-mg/kg sildenafil citrate. Sildenafil citrate might be proposed as a potential ergogenic aid through antiperipheral fatigue.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Exhaustive swimming exercise
Lactate analysis
Western blot analysis
Statistical analysis
RESULTS
Effect of sildenafil citrate on exhaustive swimming time
Effect of sildenafil citrate on lactate concentration
Effect of sildenafil citrate on MCT1 and MCT4 expressions in the gastrocnemius
Effect of treadmill exercise on nNOS expression in the gastrocnemius muscles
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Bo-Kyun Kim [ Department of Emergency Technology, College of Health Science, Gachon University, Incheon, Korea ]
• Young-Je Sim [ Department of Physical Education, Kunsan National University, Gunsan, Korea ]
• Mal-Soon Shin [ College of Culture and Sports, Division of Global Sport Studies, Korea University, Sejong, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613