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Bioactive effects of hypholomine B and davallialactone isolated from Sanghwang mushroom, Pellinus linteus KACC93057P

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    버섯 바로가기
  • 통권
    제23권 2호 통권 40호 (2019.10)바로가기
  • 페이지
    pp.74-74
  • 저자
    Gyeong-Jin Min, Chan-jung Lee, Bong-Sik Yun, Hee-Wan Kang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A364665

원문정보

초록

영어
The aim of this study was to identify styrylpyrone-class polyphenols with anti-inflammation and anticancer from fruiting body of Phellinus linteus KACC93057P that was artificially cultivated on oak logs. The fruiting body was extracted using methanol and partitioned using hexane, chloroform, ethyl acetate, and butanol, successively. The ethyl acetate-soluble layer was further separated using silica gel and Sephadex LH-20 column chromatography and preparative HPLC to provide three polyphenolic compounds. These compounds were identified as hispidin, hypholomine B, and davallialactone based on mass and NMR spectroscopic methods. The hypholomine B and davallialactone showed proliferative activity over 50% in LPS (lipopolysaccharide) -activated RAW 264.7 cell at 250 μg/mL, while hispidin exhibited an inhibitory effect on the cell viability of 30%. Hypholomine B, and davallialactone inhibited NO production of LPS activated RAW 264.7 cell by 25-95% in at the concentrations (15-250 μg/mL), showing their effects on anti-inflammation. The compounds inhibited cytokines, IL-6 and TNF- production of 83-93% in the cell at 100 μg/mL and further they showed inhibition rate of 42-50% in HCT116 human colon cancer cells at concentration of each 250 μg/mL, showing morphological alternations with cell shrinkage and irregularity of shape in the cancer cells.

저자

  • Gyeong-Jin Min [ Mushroom Research Division. Department National Institute of Horticultural & Herbal Science, RDA, Eumseong, 27709, Korea, Department of Horticultural life Science ]
  • Chan-jung Lee [ Mushroom Research Division. Department National Institute of Horticultural & Herbal Science, RDA, Eumseong, 27709, Korea ]
  • Bong-Sik Yun [ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Gobong-ro 79, Iksan 54596, Korea ]
  • Hee-Wan Kang [ Department of Horticultural life Science, JK BioTech. Ltd, Hankyong National University, Ansung 456-749, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    버섯 [Mushroom]
  • 간기
    반년간
  • 수록기간
    1997~2025
  • 십진분류
    KDC 525 DDC 635

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