Earticle

초록

영어

Nicotine withdrawal symptoms comprise insomnia, depression, anxiety, attention disorders, and increased craving. We evaluated the amelio-rating effect of treadmill exercise on nicotine withdrawal symptoms. The rats in the nicotine withdrawal groups received subcutaneous in-jection with 6-mg/kg nicotine hydrogen tartrate salt for 17 days. And then, the injection of nicotine hydrogen tartrate salt was stopped next for 2 weeks. The rats in the exercise groups performed treadmill run-ning once a day, 5 days per week, for 31 days. In the present results, activity was decreased and anxiety-like behavior was observed in the nicotine withdrawal rats. Treadmill running increased activity and ame-liorated anxiety-like behavior in the nicotine-withdrawal rats. Expres-sions of tryptophan hydroxylase (TPH) and 5-hydroxytryptamine (5-HT) in the dorsal raphe were decreased in the nicotine withdrawal rats, in contrast, treadmill running increased TPH and 5-HT expressions. Im-paired short-term memory and deteriorated spatial learning ability were observed in the nicotine withdrawal rats, in contrast, treadmill running ameliorated impairment of short-term memory and spatial learning abil-ity. Expressions of brain-derived neurotrophic factor and tyrosine kinase B (TrkB) were decreased in the nicotine withdrawal rats, in contrast, treadmill running increased brain-derived neurotrophic factor and TrkB expressions. The numbers of the dou¬blecortin (DCX)-positive cells and 5-bromo-2´-deoxyuridine (BrdU)-positive cells in the dentate gyrus were suppressed in the nicotine withdrawal rats, in contrast, treadmill run-ning enhanced the numbers of DCX-positive cells and BrdU-positive cells. The present study demonstrate that treadmill exercise ameliorat-ed nicotine withdrawal-induced anxiety, depression, and memory im-pairment.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
Nicotine injection and withdrawal
Treadmill exercise
Open field test
Elevated plus-maze test
Step-down avoidance test
Morris water maze test
Tissue preparation
Immunohistochemistry for DCX
Immunohistochemistry for BrdU
Immunohistochemistry for TPH and 5-HT
Western blotting for BDNF and TrkB
Statistical analysis
RESULTS
Behavior test
The numbers of TPH-positive and 5-HT-positive cells in the dorsal raphe
The numbers of DCX-positive and BrdU-positive cells in the dentate gyrus
Expressions of BDNF and TrkB in hippocampus
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ School of Global Sport Studies, Korea University, Sejong, Korea ]
• Hye-Sang Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, Exercise Rehabilitation Research Institute, Department of Sport & Health Science, Sangmyung University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Baek-Vin Lim [ Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613