Earticle

초록

영어

Bilateral common carotid arteries occlusion (BCCAO) causes an abrupt reduction of cerebral blood flow, and this method has been used to in-vestigate the effects of chronic cerebral hypoperfusion on vascular de-mentia and neuronal injuries. Chronic cerebral hypoperfusion leads to functional changes in the hippocampus and then results in a cognitive impairment. We investigated the effect of preischemic treadmill exer-cise on short-term memory and blood-brain barrier integration following cerebral hypoperfusion caused by BCCAO. The rats in the preischemic treadmill exercise and BCCAO group were made to run on a treadmill for 30 min once a day for 4 weeks. At 4 weeks after performing treadmill exercise, right carotid artery was ligated, and 1 week after, left common carotid artery was ligated. At 20 days after BCCAO, short-term memory was evaluated. Half of the rats were sacrificed 2 days after BCCAO and the other rats were sacrificed at 3 weeks after BCCAO. Immunohisto-chemistry and western blot were performed. Preischemic treadmill ex-ercise alleviated impairment of short-term memory in the step-down avoidance task. Preischemic treadmill exercise reduced microvascular injury in the hippocampus. Preischemic treadmill exercise prevented the reduction of zonula occludens-1 in the hippocampus and inhibited the activation of matrix metalloproteinase-9. Therefore, pre-condition-ing treadmill exercise might be used as a therapeutic strategy for the prevention of stroke in patients.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Treadmill exercise protocol
BCCAO
Step-down avoidance test
Immunohistochemistry
Western blot analysis
Statistical analysis
RESULTS
Preischemic treadmill exercise alleviates short-term memory impairment after BCCAO
Preischemic treadmill exercise prevents damage to microvessels in the hippocampal CA1 region after BCCAO
Preischemic treadmill exercise prevents the loss of tight junction and inhibits activation of MMP-9 in the hippocampus after BCCAO
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Jae-Min Lee [ Department of Sport & Health Science, College of Art & Culture, Sangmyung University, Seoul, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Science, College of Art & Culture, Sangmyung University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hye-Sang Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jong-Min Park [ College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Youn-Jung Kim [ College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Hyun-Seob Lee [ Department of Physical Education, Korea University, Seoul, Korea ]
• Mal-Soon Shin [ School of Global Sport Studies, Korea University, Sejong, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613