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Effects of acute exercise on mitochondrial dynamics and mitophagy in the rat skeletal muscles

첫 페이지 보기
  • 발행기관
    한국운동재활학회 바로가기
  • 간행물
    한국운동재활학회 학술대회 바로가기
  • 통권
    2018년 한국운동재활학회ㆍ협회 추계학술대회 (2018.10)바로가기
  • 페이지
    pp.118-118
  • 저자
    Su-Zi Yoo, Jun-Won Heo, Mi-Hyun No, Dong-Ho Park, Ju-Hee Kang, Hyo-Bum Kwak
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A354968

원문정보

초록

영어
The current study aims to investigate how mitochondrial dynamics and mitophagy are changed by a single bout aerobic exercise. Four month Fischer 344 rats were divided into 2 groups: sedentary group (SED, n=6) and acute exercise group (AEX, n=6). Rats were performed in a single bout treadmill exercise for 60 minutes. Mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, BNIP3, LC3) were measured in the permeabilized skeletal muscles (e.g., soleus, white gastrocnemius). Mitochondrial fusion-related protein (Opa1) was decreased in soleus of AEX compared with SED. Also, mitochondrial fission-related protein (Drp1) was reduced in soleus of AEX compared with SED. Similarly, in soleus muscle of AEX, mitochondrial autophagy-related protein (LC3) was decreased compared with SED. However, other proteins of mitochondrial dynamics and mitophagy didn’t show significant difference in soleus and white gastrocnemius. A single bout aerobic exercise showed tissue-specific results in mitochondrial dynamics and mitophagy. It demonstrates that acute aerobic exercise may improve mitochondrial function predominantly in soleus muscle (type I fiber). However, further research is needed to understand the cellular and molecular mechanism by which acute aerobic exercise affects mitochondrial dynamics and mitophagy in different types of muscle fibers.

저자

  • Su-Zi Yoo [ Department of Kinesiology, Inha University, Incheon, Korea, WCSL, Inha University, Incheon, Korea ]
  • Jun-Won Heo [ Department of Kinesiology, Inha University, Incheon, Korea, WCSL, Inha University, Incheon, Korea ]
  • Mi-Hyun No [ Department of Kinesiology, Inha University, Incheon, Korea, WCSL, Inha University, Incheon, Korea ]
  • Dong-Ho Park [ Department of Kinesiology, Inha University, Incheon, Korea, WCSL, Inha University, Incheon, Korea ]
  • Ju-Hee Kang [ WCSL, Inha University, Incheon, Korea, Department of Pharmacology & Clinical Pharmacology, Inha University, Incheon, Korea ]
  • Hyo-Bum Kwak [ Department of Kinesiology, Inha University, Incheon, Korea, WCSL, Inha University, Incheon, Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    한국운동재활학회 학술대회
  • 간기
    부정기
  • 수록기간
    2011~2025
  • 십진분류
    KDC 517 DDC 613

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