Earticle

초록

영어

Exercise therapy on skeletal muscle of muscular dystrophies has no defined parameters. The effect of low-intensity treadmill training on the oxidative stress markers and fibrosis on hindlimb muscles was investi-gated. Sixteen dystrophic male mdx animals were separated in trained (mdxT/n=8) and untrained (mdxNT/n=8) groups. Wild type animals (WT/n=8) were used as healthy control. The mdxT group runned at a horizontal treadmill (9 m/min, 30 min/day, 3 times/wk, 8 weeks). Gastroc-nemius and tibial anterior muscles were collected for analysis of enzy-matic/non-enzymatic oxidant activity, oxidative damage concentration, collagen fibers area morphometry. The mdxT group presented a lower collagen fiber area compared to mdxNT for gastrocnemius (P=0.025) and tibial anterior (P=0.000). Oxidative damage activity was higher in the mdxT group for both muscles compared to mdxNT. Catalase pre-sented similar activity for tibial anterior (P=0.527) or gastrocnemius (P=0.323). Superoxide dismutase (P=0.003) and total antioxidant ca-pacity (P=0.024) showed increased activity in the mdxT group at tibial anterior with no difference for gastrocnemius. Low-intensity training is considered therapeutic as it reduces collagen deposition while improv-ing tissue redox status.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental design
Low-intensity training protocol
Biological sample collection
Histological and histochemical analysis
Intramuscular collagen deposition
Redox status markers
Statistical analysis
RESULTS
Intramuscular collagen deposition
Markers of oxidative stress analysis
Antioxidant enzyme system analysis
Antioxidant system x collagen fiber deposition correlation
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Danielle Cristina Fernandes [ Department of Physical Therapy, Post Graduate Program of Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Jessica Junia A. Cardoso-Nascimento [ Department of Physical Therapy, Post Graduate Program of Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Bruna Caroline C. Garcia [ Post Graduate Program in Physiological Science, Brazilian Society of Physiology, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Karine Beatriz Costa [ Post Graduate Program in Physiological Science, Brazilian Society of Physiology, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Etel Rocha-Vieira [ Post Graduate Program in Physiological Science, Brazilian Society of Physiology, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Murilo Xavier Oliveira [ Department of Physical Therapy, Post Graduate Program of Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Alex Sander D. Machado [ Post Graduate Program in Physiological Science, Brazilian Society of Physiology, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Ana Paula Santos [ Department of Physical Therapy, Post Graduate Program of Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ]
• Thaís Peixoto Gaiad [ Department of Physical Therapy, Post Graduate Program of Rehabilitation and Functional Performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613