Earticle

초록

영어

This study investigated whether Ganoderma lucidum (Y2)-mediated fermentation of Artemisia capillaris extract (ACE) could synergistically enhance its antioxidant, anti-inflammatory, and tyrosinase-inhibiting activities. Both G. lucidum extract and fermented ACE exhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability, but with poorer efficacy than ACE (even at a low ACE concentration). Viability of RAW264.7 macrophages was significantly reduced in the presence of ACE (150 mg/mL and above). However, this effect was greatly mitigated upon G. lucidum-mediated ACE fermentation. Additionally, relative to the same concentration (25 μg/mL) of G. lucidum mycelial extract, ACE exhibited an improved ability to significantly inhibit RAW264.7 macrophage nitric oxide (NO) production. Finally, relative to the same concentration (200 μg/mL) of a positive control (arbutin), fermented ACE exhibited an approximately 3.66 times higher capacity for tyrosinase inhibition. These results suggest that G. lucidum-fermented ACE possesses enhanced tyrosinase-inhibiting activity and may be of utility as a skin-lightening agent.

목차

ABSTRACT
서론
재료 및 방법
공시시료 및 균주
인진쑥 영지균사 발효
인진쑥 영지균사 발효 추출물 제조
DPPH radical 소거 활성
RAW 264.7 세포 nitric oxide 생성량 및 생존률 측정
Tyrosinase 억제 활성 분석
통계처리
결과 및 고찰
인진쑥 영지균사 발효 추출물의 DPPH radical 소거 활성
인진쑥 영지균사 발효 추출물이 RAW 264.7 생존률 및 NO 생성에 미치는 영향
인진쑥 영지균사 발효 추출물이 tyrosinase 활성에 미치는 영향
적요
REFERENCES

키워드

저자

• 정용운 [ Yong-Un Jeong | 건국대학교 의료생명대학 바이오융합과학부 ]
• 이창수 [ Chang-Soo Lee | 건국대학교 의료생명대학 바이오융합과학부 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국버섯학회지 [Journal of MUSHROOMS]

• 간기

  계간

• pISSN

  1738-0294

• eISSN

  2288-8853

• 수록기간

  2003~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 525 DDC 635