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Original Article

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training

첫 페이지 보기
  • 발행기관
    한국운동재활학회 바로가기
  • 간행물
    JER SCOPUS KCI 등재 바로가기
  • 통권
    Vol.14 No.3 (2018.06)바로가기
  • 페이지
    pp.489-496
  • 저자
    Felipe Stigger, Silvia Barbosa, Marília Rossato Marques, Ethiane Segabinazi, Otávio Américo Augustin, Matilde Achaval, Simone Marcuzzo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A331861

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원문정보

초록

영어
The purpose of the current study was to investigate whether locomotor stimulation training could have beneficial effects on spinal cord plastici-ty consequent to sensorimotor restriction (SR). Male Wistar rats were exposed to SR from postnatal day 2 (P2) to P28. Control and experimen-tal rats underwent locomotor stimulation training in a treadmill from P31 to P52. The intensity of the synaptophysin and caspase-3 immunoreac-tion was determined on ventral horn of spinal cord. The synaptophysin immunoreactivity was lower in the ventral horn of sensorimotor restrict-ed rats compared to controls animals and was accompanied by an in-creased caspase-3 immunoreactivity. Those alterations were reversed at the end of the training period. Our results suggest that immobility af-fects the normal developmental process that spinal cord undergoes in early postnatal life influencing both pro-apoptotic and synapse markers. Also, we demonstrated that this phenomenon was reversed by 3 weeks of treadmill training.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals
  Immunoistochemical procedure
  Optical densitometry
  Neonatal developmental tests
  Statistical analysis
 RESULTS
  Optical densitometry
  Neonatal developmental tests
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

Developmental disuse Apoptosis Spinal cord plasticity Treadmill walking training

저자

  • Felipe Stigger [ Department of Physiotherapy, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil ] Corresponding author
  • Silvia Barbosa [ Laboratory of Comparative Histophysiology, Department of Morphological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]
  • Marília Rossato Marques [ Postgraduation Program of Neurosciences, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]
  • Ethiane Segabinazi [ Postgraduation Program of Neurosciences, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]
  • Otávio Américo Augustin [ Laboratory of Comparative Histophysiology, Department of Morphological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]
  • Matilde Achaval [ Postgraduation Program of Neurosciences, Department of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]
  • Simone Marcuzzo [ Postgraduation Program of Neurosciences, Department of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    JER [Journal of Exercise Rehabilitation]
  • 간기
    격월간
  • pISSN
    2288-176X
  • eISSN
    2288-1778
  • 수록기간
    2013~2026
  • 등재여부
    SCOPUS,KCI 등재
  • 십진분류
    KDC 517 DDC 613

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