Earticle

초록

영어

Alzheimer disease (AD) is a most common form of dementia and even-tually causes impairments of learning ability and memory function. In the present study, we investigated the effects of treadmill exercise on the symptoms of AD focusing on the microglial activation-induced apoptosis. AD was made by bilateral intracerebroventricular injection of streptozotocin. The rats in the exercise groups were made to run on a treadmill once a day for 30 min during 4 weeks. The distance and la-tency in the Morris water maze task and the latency in the step-down avoidance task were increased in the AD rats, in contrast, treadmill ex-ercise shortened these parameters. The numbers of terminal deoxynu-cleotidyl transferase-mediated dUTP nick end labeling-positive and caspase-3-positive cells in the hippocampal dentate gyrus were de-creased in the AD rats, in contrast, treadmill exercise suppressed these numbers. Expressions of glial fibrillary acidic protein (GFAP) and cluster of differentiation molecule 11B (CD11b) in the hippocampal dentate gy-rus were increased in the AD rats, in contrast, treadmill exercise sup-pressed GFAP and CD11b expressions. Bax expression was increased and Bcl-2 expression was decreased in the hippocampus of AD rats, in contrast, treadmill exercise decreased Bax expression and increased Bcl-2 expression. The present results demonstrated that treadmill exer-cise ameliorated AD-induced impairments of spatial learning ability and short-term memory through suppressing apoptosis. The antiapoptotic effect of treadmill exercise might be ascribed to the inhibitory effect of treadmill exercise on microglial activation.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of AD
  Exercise protocol
  Morris water maze task
  Step-down avoidance task
  Tissue preparation
  TUNEL assay
  Immunohistochemistry for caspase-3, GFAP, and CD11b
  Western blotting for Bax and Bcl-2
  Statistical analysis
 RESULTS
  Effect of treadmill exercise on the spatial learning ability
  Effect of treadmill exercise on the short-term memory
  Effect of treadmill exercise on the DNA fragmentation in the hippocampal dentate gyrus
  Effect of treadmill exercise on the caspase-3 expression in the hippocampal dentate gyrus
  Effect of treadmill exercise on the GFAP expression in the hippocampal dentate gyrus
  Effect of treadmill exercise on the CD11b expression in the hippocampal dentate gyrus
  Effect of treadmill exercise on the Bax and Bcl-2 expressions in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Seung-Soo Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ] Corresponding author
• Sang-Hoon Kim [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613