Earticle

초록

영어

Adolescence is a critical period for neurodevelopment, neuronal plas-ticity, and cognitive function. Experiences of adolescence can be exert-ed positive and negative effects on brain development. Physical exer-cise has a positive effect on brain function, which is characterized by improving memory function and increased neural plasticity. High fat diet (HFD)-induced obesity has a negative effect on brain function, which is characterized by insulin resistance and neuroinflammation and re-duced microvessel constructure. Although the positive effect of exer-cise and negative effect of obesity on cognitive function have been documented, it has not been well whether comparison of the effects of exercise and obesity on cognitive function in adolescent rats. In the present study, we evaluated the behavioral changes related to cogni-tive function induced by exercise and obesity in adolescent rats. Male Wistar rats were randomly divided into three groups: the control group (CON), the exercise group (Ex), the high fat diet group (HFD). The HFD containing fat 60% was freely provided. The present results showed that spatial learning ability and short-term memory did not show signifi-cant effect exercise as compared to the control group. The present re-sults showed that spatial learning ability and short-term memory was significantly decreased HFD-induced obesity group as compared to the control group. These results suggest that positive effect of physical ex-ercise in adolescence rats may be exerted no significant effect on cog-nitive function. But, negative effect of HFD-induced obesity might in-duce cognitive impairment. HFD-induced obesity in adolescent rats may be used as an animal model of neurodevelopmental disorders.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and housing conditions
  Treadmill exercise protocol
  Morris water maze test
  Step-down avoidance test
  Statistical analysis
 RESULTS
  Effects of exercise and obesity on body weight
  Effects of exercise and obesity on spatial learning ability in the Morris water maze test
  Effects of exercise and obesity on short-term memory in step-down avoidance test
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Jae-Min Lee [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jong-Min Park [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Min Kyung Song [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Yoon Ju Kim [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ]
• Youn-Jung Kim [ Department of Basic Nursing Science, College of Nursing Science, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613