Nitric oxide (NO) is one of major inflammatory mediators which can provoke inflammatory reactions to infections. It is well known that excessive production ofNO is implicated in the pathogenesis of many diseases such as atherosclerosis, neurodegenerative diseases, inflammatory autoimmune diseases, and cancer. Gardeniae Fructus (the matured fruit of Gardeniajasminoides) is traditionally used to treat inflammation in East Asia including Korea, China, and Japan. In the present study, Gardeniae Fructus water extract (GFW) at concentrations of 10, 25, 50, 100, and 200ug/mL increased the cell viability of mouse macrophages RAW 264.7 and reduced NO production ofRAW 264.7 significantly (P<0.05). And GFW at concentrations of I 0, 25, 50, 100, and 200ug/mL significantly inhibited LPS-induced production of NO in RAW 264.7 (P<0.05). These results mean that GFW might have anti-inflammatory activity concerned with modulation of NO production in immune reaction. Further detailed studies deserve to elucidate the exact mechanism of anti-inflammatory activity of GFW in macropahges.
목차
ABSTRACT INTRODUCTION MATERIALS AND METHODS Materials Methods Statistical analysis Results Effects of GFW on Cell Viability Effects of GFW on NO production DISUSSION CONCLUSION ACKNOWLEDGEMENTS REFERENCE
저자
Bu Min KIM [ 10, Geomapyeong-ro, Wansan-gu, Jeonju-si, Jeollabuk-do, Korea ]
국제과학영재학회 [The Society for the International Gifted in Science]
설립연도
2006
분야
자연과학>자연과학일반
소개
과학영재를 위한 연구 활동을 통하여 과학영재를 발굴하고, 발굴된 과학영재가 과학 분야의 관련 연구 활동을 할 수 있도록 지원하여, 이들이 과학 관련 분야의 진로를 선택하도록 장려함으로써 국제경쟁력을 갖춘 우수 과학기술인을 배출하고 국가 경제발전 및 문화창달과 세계 과학 발전에 기여함을 목적으로 한다.
간행물
간행물명
APEC Youth Scientist Journal [APEC 청소년 과학학술지]
간기
반년간
pISSN
2005-5625
수록기간
2009~2022
십진분류
KDC 405DDC 505
이 권호 내 다른 논문 / APEC Youth Scientist Journal Vol. 8 No.1