Earticle

초록

영어

Social isolation is known to induce emotional and behavioral changes in animals and humans. The effect of treadmill exercise on depression was investigated using social isolated rat pups. The rat pups in the social isolation groups were housed individually. The rat pups in the exercise groups were forced to run on treadmill for 30 min once a day from postnatal day 21 to postnatal day 34. In order to evaluate depression state of rat pups, forced swimming test was performed. Newly generated cells in the hippocampal dentate gyrus were determined by 5-bromo- 2’-deoxyuridine (BrdU) immunohistochemistry. We examined the expression of 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) in the dorsal raphe using immunofluorescence. The expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) was detected by Western blot analysis. The present results demonstrated that social isolation increased resting time and decreased mobility time. Expression of 5-HT and TPH in the dorsal raphe and expression of BDNF and TrkB in the hippocampus were decreased by social isolation. The number of BrdU-positive cells in the hippocampal dentate gyrus was suppressed by social isolation. Treadmill exercise decreased resting time and increased mobility in the social isolated rat pups. Expression of 5-HT, TPH, BDNF, and TrkB was increased by treadmill exercise. The present results suggested that treadmill exercise may ameliorates social isolation-induced depression through increasing neuronal generation.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Treadmill exercise protocol
  Forced swimming test
  Tissue preparation
  Immunofluorescence for 5-hydroxytryptamine and tryptophan hydroxylase expression
  Immunohistochemistry for BrdU
  Western blot analysis
  Data analysis
 RESULTS
  Effect of treadmill exercise on depression
  Effect of treadmill exercise on the 5-HT synthesis and TPH expression
  Effect of treadmill exercise on neurogenesis
  Effect of treadmill exercise on BDNF and TrkB expression
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Jung-Wan Cho [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sun-Young Jung [ Department of Physical Therapy, Hosan University, Gyeongsan, Korea ]
• Sang-Won Lee [ Department of Physical Education, Korea Military Academy, Seoul, Korea ]
• Sam-Jun Lee [ Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Young-Pyo Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Dae-Young Kim [ Department of Sports Healthcare, College of Humanities & Social Sciences, Inje University, Gimhae, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613