Earticle

초록

영어

The effect of maternal forced exercise on central disorders in offsprings has been shown but the mechanism is still unclear. In this study, the role of 5-HT2 and D2 receptors in neuroprotective effects of maternal forced exercise on offspring neurodevelopment and neurobehavioral symptoms is evaluated. Sixty pregnant rats were trained by forced ex-ercise and some behavioral and molecular aspects in their offspring were evaluated in presence of 5-HT2 and D2 receptors agonists and an-tagonists. The results showed that maternal forced exercise causes in-crease of pain tolerability and increase latency of pain perception in offspring in hot plate test, writhing test and tail flick test. Also maternal forced exercise causes decrease of depression and anxiety like behav-ior in offsprings. On the other hand, treatment of mothers by forced ex-ercise in combination with 5-HT2 and D2 receptor antagonists inhibited the protective effects of forced exercise and cause disturbance in pain perception and tolerability and increase depression and anxiety in off-springs. Also expression of cyclic AMP response element binding pro-tein (CREB) was changed in all experimental groups. In conclusion, our data suggested that maternal forced exercise causes neurobehavioral protective effect on offsprings and this effect might probably be mediat-ed by 5-HT2 and D2 receptors and activation of CREB gene expression.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animal
  Drug
  Experimental design of pregnant rats
  Treadmill forced exercise protocol
  Behavioral and molecular assays in offspring
  Writhing test
  Tail flick test
  Hot plate test
  Open field test
  Quantitative real-time reverse transcription-polymerase chain reaction studies
  Hematoxylin and eosin staining
  Neuropathological examination
  Statistical analysis
 RESULTS
  The effect of maternal exercise and the role of D2 and 5-HT2 receptors on offsprings’ pain response in WT
  The effect of maternal forced exercise and the role of D2 and 5-HT2 receptors on offsprings’ pain response in TFT
  The effect of maternal exercise and the role of D2 and 5-HT2 receptors on offsprings’ pain response in HPT
  The effect of maternal exercise and the role of D2 and 5-HT2 receptors on offsprings’ OFT behavior assay
  The effect of maternal exercise and the role of D2 and 5-HT2 receptors on offsprings’ anxiety like behavior in EPM
  The alteration in CREB gene expression in offsprings
  The alteration in cell density and morphology of DG in offsprings
  The correlation between hippocampal CREB expression and gentate gyrus cell density
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Ozra Motaghinejad [ Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ]
• Majid Motaghinejad [ Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ] Corresponding author
• Manijeh Motevalian [ Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ]
• Fatemeh Rahimi-Sharbaf [ Department of Gynecology, Tehran University of Medical Sciences, Tehran, Iran ]
• Tabassom Beiranvand [ Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613