Earticle

초록

영어

Maximal whole body exercise leads skeletal muscle blood flow to markedly increase to match metabolic demands, a phenomenon termed exercise hyperaemia that is accomplished by increasing vaso-dilation. However, local vasodilatory mechanisms in response to skele-tal muscle contraction remain uncertain. This review highlights meta-bolic vasodilators released from contracting skeletal muscle, endotheli-um, or blood cells. As a considerable skeletal muscle vasodilation po-tentially results in hypotension, sympathetic nerve activity needs to be augmented to elevate cardiac output and blood pressure during dy-namic exercise. However, since the enhanced sympathetic vasocon-striction restrains skeletal muscle blood flow, intramuscular arteries have an indispensable ability to blunt sympathetic activity for exercise hyperaemia. In addition, we discuss that mechanical compression of the intramuscular vasculature contributes to causing the initial phase of increasing vasodilation following a single muscle contraction. We have also chosen to focus on conducted (or ascending) electrical signals that evoke vasodilation of proximal feed arteries to elevate blood flow in the microcirculation of skeletal muscle. Endothelial hyperpolarization originating within distal arterioles ascends into the proximal feed arter-ies, thereby increasing total blood flow in contracting skeletal muscle. This brief review summarizes molecular mechanisms underlying the regulation of skeletal muscle blood flow to a single or sustained muscle contraction.

목차

Abstract
 INTRODUCTION
 METABOLIC VASODILATORY FACTORS
 FUNCTIONAL SYMPATHOLYSIS
 MECHANICAL COMPRESSION
 ENDOTHELIUM-DERIVED HYPERPOLARIZATION AND CONDUCTED VASODILATION
 CONCLUSIONS
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Kwang-Seok Hong [ Robert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA ]
• Kijeong Kim [ School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613