Earticle

초록

영어

Purpose: The optimum formulation and preparation process of ferulic acid self microemulsion was studied. Methods: The effect of different surfactants on the formation of microemulsion area was studied by pseudo three phase diagram method. To determine the best ratio among surfactants, cosurfactant and oil phase, the uniformity and particle size of microemulsion was evaluated by nanoparticle size analyzer. Finally, the stability of microemulsion was measured by nanoparticle size analyzer and zeta potential analyzer. Results: Combined the results of pseudo three phase diagram with particle size distribution, the best ratio of self microemulsion:polyoxyethylene castor oil (Cremophor EL): polyethylene glycol 40 (PEG 40):Ethanol:isopropyl myristate (IPM) is about 3.15:3.15:1.8:1. The average particle size of microemulsion is about 15.5 nm which of system contains about 90% water. The maximum drug loading of ferulic acid was 5.2%, and this self microemulsion formulation has good stability. Conclusion: The formula greatly improves the solubility of insoluble materials like ferulic acid in water and it has guiding significance for the application of the microemulsion in practical production.

한국어

목적: 본 연구는 페룰산의 자체 에멀젼을 위한 최적의 포뮬러 및 제조공정을 연구 하기 위한 것이다. 방법: Pseudo three phase diagram방법을 이용하여 각기 다른 계면활성제의 마이크로 에멀젼 영역의 형성 크기에 대한 영향을 연구하고, 또한 SZ-100나노입 자분석기를 이용하여, 계면활성제, 보조계면활성제, 오일의 최적의 비율을 확인하였다. 마지막으로 SZ-100나노입자분석기 및 Zeta 전위 분석기를 이용하여 마이크로 에멀젼의 안정성을 확인하였다. 결과: Pseudo three phase diagram방법과 SZ-100나노입자분석 기를 이용하여 측정한 결과를 종합하여, 최적의 에멀젼 처방비율은 polyoxyethylene castor oil (Cremophor EL):polyethylene glycol 40 (PEG 40):무수에탄올:isopropyl myristate (IPM)=3.15:3.15:1.8:1 이고, 에멀젼의 평균입자크기는 15.5 nm 이며, 이때 마이크로 에 멀젼 체계 수분함량은 90% 이었다. 페롤산의 최대 약물적재량(maximum drug loading)은 5.2% 이며, 에멀젼의 안정성 또한 우수하 다는 것을 확인하였다. 결론: 위와 같은 에멀젼 처방의 연구는 페롤산과 같은 불용성 물질의 수중에서의 용해도를 대폭 증가시킴으 로써, 실제 생산응용 시에 중요한 가치를 가질 것으로 사료된다

중국어

目的: 研究阿魏酸自微乳最佳配方及制备工艺。方法: 采用伪三相图法研究不同表面活性剂对微乳区形成大小的影 响，并且采用SZ-100纳米粒度分析仪确定表面活性剂、助表面活性剂与油相的最佳比例；最后利用SZ-100纳米粒 度/Zeta电位分析仪评价微乳质量。结果: 综合伪三相图法和粒度分布仪的结果，确定了不含阿魏酸的自微乳体系 的最佳配方为 polyoxyethylene castor oil (Cremophor EL):polyethylene glycol 40 (PEG 40):无水乙醇:isopropyl myristate (IPM)=3.15:3.15:1.8:1，微乳平均粒径为15.5 nm (体系水分含量为90%)，阿魏酸的最大载药量为5.2%，其 自微乳配方稳定性良好。结论: 该配方较大的提升了阿魏酸这种难溶性原料在水中的溶解度，对于将该微乳液应用于 实际生产具有指导意义。

목차

Abstract
 Introduction
 Methods
  1. Instruments and materials
  2. Determination of surfactants
  3. Optimization of surfactant and cosurfactant ratio
  4. Determination the ratio of mixed surfactant to oil phase
  5. Ferulic acid microemulsion
  6. Identification and quality evaluation of ferulic acid microemulsion
  7. Data processing and analysis
 Results & Discussion
  1. Screening results of surfactants
  2. Determination of the ratio of surfactant to cosurfactant
  3. Determination of the ratio of mixed surfactant to oil phase
  4. The maximum loading and stability of ferulic acid
  5. Quality evaluation of ferulic acid
 Conclusion
 References
 中文摘要
 국문초록

키워드

미백 페룰산 처방공정 마이크로 에멀젼 약물적재량 Whitening Ferulic acid Formulation process Microemulsion Drug loading 美白 阿魏酸 配方工艺 微乳液 载药量

저자

• Jinhui Zuo [ 좌금휘 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ]
• Qiang Li [ 이강 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ]
• Zeyuan Dong [ 동탁원 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ]
• Hong Meng [ 맹홍 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ]
• Li Li [ 리려 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ]
• Yinmao Dong [ 동은묘 | China Cosmetic Collaborative Innovation Center, Beijing Technology and Business University, Beijing, China ] Corresponding author

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