Earticle

초록

영어

Maternal obesity exerts negative effects on cognitive function and be-havior of the offspring. In the present study, we assessed the effects of paternal physical exercise on spatial learning ability in relation with hip-pocampal neuroplasticity in the rat pups born from the obese maternal rats. There were four experimental groups: paternal nonexercised male pups from normal maternal rats, paternal exercised male pups from normal maternal rats, paternal nonexercised male pups from obese maternal rats, and paternal exercised male pups from obese maternal rats. Normal diet was supplied for normal maternal rats and high-fat diet was supplied for obese maternal rats for a 12-week period until mating, and the same diet for each group continued throughout pregnancy and lactation period. Male rats in the exercising groups exercised for a 12-week period. Spatial learning ability was reduced in the male rat pups born from the obese maternal rats. Expressions of brain-derived neuro-trophic factor (BDNF) and tyrosine kinase B receptor (TrkB) in the hip-pocampus were suppressed and cell proliferation and differentiation in the hippocampus were reduced in the male rat pups born from the obese maternal rats. Paternal treadmill exercise improved spatial learn-ing ability, increased BDNF and TrkB expressions, and enhanced cell proliferation and differentiation in the male rat pups born from the obese maternal rats. It can be suggested that paternal exercise enhances hip-pocampal neuroplasticity and consequently improved spatial learning ability in the rat pups born from the obese maternal rats.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Morris water maze task
  Tissue preparation
  Immunohistochemistry for BrdU
  Immunohistochemistry for DCX
  Western blotting for BDNF and TrkB
  Statistical analyses
 RESULTS
  Effect of paternal treadmill exercise on spatial learning ability in male rat pups
  Effect of paternal treadmill exercise on BDNF and TrkB expressions in male rat pups
  Effect of paternal treadmill exercise on cell differentiation in male rat pups
  Effect of paternal treadmill exercise on cell proliferation in male rat pups
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Hye-Sang Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613